antiseizure meds Flashcards Preview

MOHD IV > antiseizure meds > Flashcards

Flashcards in antiseizure meds Deck (19):
1

partial complex seizure tx

-phenytoin, carbamazepine, lamortigine, levetiracetam
-gabapentin

2

generalized tonic clonic tx

-phenytoin, carbamazepine, lamortigine, levetiracetam
-phenobarbital, valproic acid

3

generalized absence tx

-ethosuximide
-clonazepam, valproic acid

4

generalized myoclonic

-clonazepam, levetiracetam, valproic acid
-lamortigine

5

generalized febrile

-phenobarbital, primidone

6

generalized status E

-phenytoin, diazepam, phenobarbital

7

phenytoin

blocks voltaged gated Na and Ca channels
drug of choice for epilepsy in adults
-partial simple
-partial complex
-tonic clonic
-emergency status E
not for absence seizures (may precipitate)
high plasma protein binding
CYP2c9 and 2c19
-dose saturation
-drug interactions
AE
-gingival hyperplasia
-megablastic anemia
-teratogen

8

phenytoin drug interaction

cyp2c9 and cyp2c19
increases metabolism of doxycycline and cyclosporine
phenytoin's metabolism increased by carbamazepine
phenytoin's metabolism decreased by chloramphemicol and sulfonamide

9

carbamazepine

voltage gated Na channels
tx
-partial simple
-partial complex
-tonic clonic
-trigeminal neuralgia
-bipolar
induces own metabolism and phenytoins
high plasma protein binding
AE hepatotoxicity, teratogen

10

valproic acid

blocks voltage gated Na and Ca channels, facilitates GABAinergic
tx
-drug of choice for myoclonic
-2nd line for tonic clonic and absence
p450 metabolism
high plasma protein binding
AE hepatotoxic, thrombocytopenia, teratogen

11

ethosuximide, methuximide, phensuximide

blocks voltage gated type T Ca channels
drug of choice for absence seizure
long half life (30-60 hours)
75% p450, 25% renal excretion

12

phenbarbital, primidone

barbiturates
GABAinergic
tx
-simple partial
-tonic clonic
-febrile
-anxiety
combined with carbamazepine and phenytoin
75% hepatic microsomal system
AE drowsiness, megablastic anemia, teratogen

13

diazepam, lorazepam, clonazepam

benzodiazepine
GABAinergic
tx
-stat E
-anxiety
-myoclonic
-absence (clonazepam)
tolerance in 1-6 months

14

lamotrigine

blocks voltage Na, inhibits GLU release
tx
-partial simple
-partial complex
-tonic clonic
metabolized by liver
-metabolism increased by carbamazepine, phenytoin
-metabolism decreased by valproic acid

15

gabapentin

blocks Ca (alpha2-delta) and GLU release
tx
-partial simple
-partial complex
-tonic clonic
-peripheral neuropathy
no interaction with liver
short 1/2 life 5-8 hours

16

pregabalin

blocks voltage gated Ca channels (alpha2-delta) and GLU release
tx
-partial simple
-partial complex
AE- thrombocytopenia

17

topiramate

blocks Na, increases post synaptic GABA receptor activity
tx
-partial simple
-partial complex
-tonic clonic

18

levetiracetam

mech unclear- GLU, GABA via synapic SV2A binding
tx
-broad spectrum for generalized or partial
-tonic clonic
-myoclonic

19

partial simple seizure medications

-phenytoin, carbamazepine, lamortigine, levetiracetam
-phenobarbital, gabapentin