antivirals Flashcards Preview

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Flashcards in antivirals Deck (25):
1

enfuvirtide

anti HIV
blocks gp41, blocks entry
peptide
AE: expensive, local inflammation

2

AZT

HIV
NRTI

3

frequently used NRTI

ABC-abacorivir-G
FTC- emtricictabine -C
3TC- lamivudine-C

4

tenofovir

HIV
A analog
competes with other nucleotide analogs for renal exretion

5

nevipine, efavirenz, delavirdine

anti hiv
small molecure RTI
allosteric hydrophobic pocket

6

dolutegravir (DTG)

HIV
integrase inhibitor

7

darunavir, ritovir

HIV
protease inhibitor
AE lipodystrophy
ritovir- cyp3a4

8

HAART formula

2 NRTI + (protease or integrase or NNRT inhibitor) + phamokinetic enhancer (ritomavir)

9

acyclovir, valacyclovir

alpha herps tx
nucleotide analogs
selective> requires viral thimidine kinase
tx
-HSV1 and 2 primary and reactivation
-VSV in immunocompromized
-BMT, organ tx prophylaxis
-HSV encephalitis

10

famciclovir

slightly different action than acyclovir
alpha herps
G analog

11

cidovir, adefovir

alpha herps
C analog
affective against Thimidine kinase - strains
competive inhibitor of DNA polymerase
-chain termination

12

foscarnet

all herps
pyrophosphate analog
non competitive inhibition of DNA polymerase
100x more selective for viral than human

13

docosanol

alpha herps
saturated fatty acid alcohol
topical
mixed evidence

14

gancyclovir

Beta and gamma herps
AE granulocytopenia and thrombocytopenia

15

fomivirsen

CMV
antisense RNA
tx CMV retinitis in immunocompromized patients

16

Beta and Gamma tx

gancyclovir
valgancyclovir
foscarnet
cidofovir
fomivirsen

17

amantadine

influenza A
blocks M2 proton pump
>blocks uncoating event
no longer effective
within 48 hours of symptoms
alternative tx anti parkinsons

18

zanamivir, oseltemivir

influenza A
neurimidase Inhibitor
prevent final step of life style

19

palivizumab (synagis)

RSV
monoclonal antibody
at risk, infants under 2

20

ribvarin

most broad spectrum AV
RSV
interferes with several guanosine dependent processes
>highly defective viral genome
>CDt4 Th2> Th1

21

tenovir

HBV
HIV RTI
well tolerated

22

entecavir

HBV
G analog
failed HIV NRTI

23

interferon alpha 2a

HBV
30-40% response

24

HCV agents

simeprevir, parataprevir > protease inhibitor
ombitasivir, lidipasvir> phosphophoprotein
sofosbuvir, dasabuvir> polymerase inhibitor

25

maravir

anti HIV
only antiviral that targets a host protein (CCR5)
blocks entry
resistance: mutation of gp120
salvage tx