antiviral/fungal

Question 1

Amantadine acts on:

Answer 1

uncoating M2 proton channel

Question 2

Rimantadine acts on:

Answer 2

Uncating, M2 proton channel

Question 3

Oseltamivir/Zanamivir/Peramivir acts on:

Answer 3

Viral neuramindase - decrease viral budding

Question 4

Acyclovior/Valacyclovir acts on:

Answer 4

viral DNA polymerase + chain termination

Question 5

Docosanol acts on:

Answer 5

inhibits fusion between plasma and HSV envelope

Question 6

Ganiciclovir/Valganciclovir acts on:

Answer 6

Viral thymidine kinase (inhibits v DNA pol)

Question 7

Cidofovir acts on:

Answer 7

nucleotide analog - viral DNA pol

Question 8

Foscarnet acts on:

Answer 8

No activation step for viral DNA/RNA pol and RT

Question 9

Ribavirin acts on:

Answer 9

inhibit IMP dehydrogenase - viral RDRP

Question 10

Amantadine/Rimantadine uses for

Answer 10

Influenza A (prophylaxis/treatment)

Question 11

Oseltamivir/zanamivir/peramivir uses for

Answer 11

influenza A/B/C

Question 12

zanamivir adverse effect

Answer 12

bronchospasm

Question 13

Acyclovir used for

Answer 13

HSV1/2 (mucosal/genital/encephalitis)

VZV

Question 14

Penciclovir route of admin

Answer 14

topical only

Question 15

Oseltamivir route of admin

Answer 15

orally

Question 16

Zanamivir route of admin

Answer 16

inhalation

Question 17

Peramivir route of admin

Answer 17

IV

Question 18

Acyclovir route of admin

Answer 18

Topical, Oral, IV

Question 19

Ganciclovir route of admin

Answer 19

poor oral/good with valganciclovir

Question 20

Ganciclovir Adverse effect:

Answer 20

bone marrow depression

Question 21

Cidofovir uses

Answer 21

CMV infection

Question 22

Cidofovir adverse effect

Answer 22

nephrotoxicity

Question 23

FOscarnet adverse effect

Answer 23

Renal imparment, hypocalcemia

Question 24

Foscarnet uses

Answer 24

CMV infection

Question 25

Ribavirin used for

Answer 25

RSV

Question 26

Ribavirin adverse effect

Answer 26

low aerosol toxicity teratogen anemia bone marrow depression

Question 27

Amphotericin mechanism

Answer 27

bind ergosterol, forms pores

Question 28

Amphotericin route of admin

Answer 28

IV or topical

Question 29

Amphotericin Uses

Answer 29

broad spectrum/systemic infection

Question 30

Amphotericin adverse

Answer 30

nephrotoxicity

Question 31

Nystatin route

Answer 31

topical only

Question 32

Nystatin uses

Answer 32

superifical candidal infection

Question 33

Caspofungin mechanism

Answer 33

inhibit synthesis of cell wall beta (1,3) - D- glucan

Question 34

Caspofungin routes

Answer 34

IV hepatic dosing DDI with CYP450

Question 35

Caspofungin uses

Answer 35

invasive aspergillosis | refractory/intolerant to other therapies

Question 36

Triazoles mechanism

Answer 36

14 a - demethylase - reudce normal sterol synthesis

Question 37

imidazoles mechanisms

Answer 37

Ketoconazole - inhibits P450 ergosterol synthesis

Question 38

Triazole/fluconazole uses

Answer 38

orophoaryngeal/esophageal candidiasis, vulvovaginal candidiasis

Question 39

Triazole adverse effect

Answer 39

inhibits CYP450

Question 40

Imidazoles adverse effect

Answer 40

inhibits CYP450 hepatotoxicity Androgen GC biosynthesis

Question 41

Ketoconazole uses

Answer 41

Dermatologic indications - systemic (candidiasis)

Question 42

Clotrimazole

Answer 42

topical/oral/vaginal candidiasis

Question 43

Terbinafine mechanism

Answer 43

squalene oxidase - reduce ergosterol synthesis | build up squalene = fatal

Question 44

Flucytosine mechanisms

Answer 44

converted to 5FU - inhibits thymidylate synthease/DNA synthesis

Question 45

Flucytosine uses

Answer 45

cryptococcosis, candidiasis

Question 46

flucytosine adverse effect

Answer 46

bone marrow depression

Question 47

Griseofulvin mechanisms

Answer 47

microtubules - inhibits mitosis

Question 48

Griseofulvin adverse effect

Answer 48

hypersensitivity reaction