Antivirals Flashcards
(20 cards)
Which antiviral is effective against HSV1 and 2?
aciclovir/valaciclovir
Which antivirals are effective against CMV?
Ganciclovir (1st line)
Foscarnet (2nd line)
Cidofovir (3rd line)
Valganciclovir
Letermovir
Mechanism of action of cidofovir?
cytidine analogue
Mechanism of action of foscarnet
direct DNA polymerase inhibitor
Mechanism of action of maribavir?
inhibits viral kinase
Mechanism of action of letermovir?
CMV DNA terminase inhibitor
Therefore CMV specific
Which antiviral is effective for influenza A
Zanamivir
Oseltamivir (tamiflu)
Which virus causes post-transplant lymphoproliferative disease?
EBV
What is the management of post-transplant lymphoprolifertive disease?
Rituximab
Antiviral with broad activity?
Ribavirin
Antiviral for hep E?
Ribavirin
Antivirals for hep B
Tenofovir
Ritonavir
Lamivudine
Zidovudine
Antiviral for COVID?
remdesivir
Monoclonal antibodies for COVID?
Ronapreve
Sotrovimab
Mechanism of sarilumab?
IL-6 receptor antagonist
Mechanism of action of oseltamivir and zanamivir?
neuraminidase inhibitors
what does BK cause?
BK haemorrhagic cystitis if bone marrow transplant
BK nephropathy if renal transplant
treatment of BK virus?
cidofovir
treatment of adenovirus?
cidofovir, if severe then IVIG
Which mutation leads to resistance o neuraminidase?
H275Y
