antivirals/fungals

Question 1

Azoles

Answer 1

fluconazole
itraconazole
voriconazole

Question 2

Azoles MOA

Answer 2

inhibits CYP450, dec prod ergosterol

Question 3

Azoles SE

Answer 3

GI, inc LFTs

Question 4

Amphotericin B MOA

Answer 4

binds ergosterol and forms pores in cell memb

Question 5

amphotericin B SE

Answer 5

infusion related (fever/chills/V/HA)
cumulative tox (renal)

Question 6

echinocandins

Answer 6

caspofungin
micafungin
anidulafungin

Question 7

echinocandins MOA

Answer 7

inhibit synth B (1-3) glucan, disrupts cell wall

Question 8

echinocandins Se

Answer 8

GI, flush

Question 9

Neurominidase inhibitors

Answer 9

oseltamivir

zanamivir

Question 10

nerominidase inhib MOA

Answer 10

analogs sialic acid, interferes w release of progeny influenza virus from infected cells

Question 11

neurominidase inhib Se

Answer 11

oselt-NV abd pain, HA, fever diarrhea, CNS

zana-cough, bronchospasm, dec PFT, nasal/throat

Question 12

M2 blockers

Answer 12

amantadine

rimantadine

Question 13

M2 blockers MOA

Answer 13

block M2 proton channels of virus inhibiting uncoating of viral RNA in host cell
against influenza A ONLY

Question 14

m2 blockers SE

Answer 14

GI (nausea/anorexia), CNS, severe behavioral changes, delirium, agitation, sz

Question 15

antivirals for HSV/VZV

Answer 15

acyclovir

valacyclovir

Question 16

antivirals for HSV/VZV MOA

Answer 16

inhib DNA synth (binds DNA template)

Question 17

antivirals for HSV/VZV Se

Answer 17

N/D HA

Question 18

antivirals for CMV

Answer 18

ganciclovir

valganciclovir

Question 19

antivirals for CMV MOA

Answer 19

acyclic guanosine analog, termination of DNAelongation

Question 20

antivirals for CMV SE

Answer 20

myelosuppression, ND, fever, periph neurop

Question 21

Azoles use

Answer 21

candida, blastomyc/coccidoido/histo, aspergillus

Question 22

Amphotericin B use

Answer 22

broadest spectrum, severe life threatening infx

Question 23

echinocandins use

Answer 23

candida, aspergillus