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Endocrinology > Appetite Control > Flashcards

Flashcards in Appetite Control Deck (12)
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1
Q

Where is the ‘satiety centre’

A

Arcuate nucleus in hypothalamus

2
Q

What types of primary neurone are in the arcuate nucleus?

A

Stimulatory neurones

Inhibitory neurones

3
Q

What do stimulatory neurones do?

A

Contain

  • neuropeptide Y
  • Agouti-related peptide

Promote hunger

4
Q

What do inhibitory neurones do?

A

Contain POMC

POMC produces

  • α-MSH
  • β-endorphin
5
Q

What is ghrelin?

A

Hormone produced by stomach when empty

Stimulates excitatory neurones in arcuate nucleus so stimulates appetite

6
Q

What inhibits ghrelin release?

A

Filling of stomach

7
Q

What is PYY?

A

Peptide tyrosine tyrosine

Released by cells in ileum and colon in response to feeding

Inhibits excitatory neurones in arcuate nucleus so suppresses appetite

8
Q

What hormones are released by gut to act on hypothalamus?

A

Ghrelin

PYY

9
Q

What is leptin?

A

Hormone released by adipocytes

Suppresses appetite

Action in arcuate nucleus

  • stimulate inhibitory neurones
  • inhibit excitatory neurones
10
Q

What effect does insulin have on appetite?

A

Suppresses appetite

11
Q

What is amylin?

A

Hormone produced by β cells in pancreas

Suppresses appetite

12
Q

What other hormones affect appetite?

A

GLP-1
Cholecytokinin
Pancreatic polypeptide