Arachidonic acid metabolism

Question 1

name some of the end product metabolites of Arachidonic acid metabolism

Answer 1

Prostacyclin
Prostanglandin
Thromboxane
Leukotrienes

Question 2

What enzyme must metabolise Arachidonic acid in order to produce Prostacyclins, Prostaglandins and thromboxane?

Answer 2

COX-1, COX-2

Question 3

Function of prostacyclins

Answer 3

decreased platelet aggregation
vasodilation
reduced uterine tone

Question 4

Function of prostaglandins

Answer 4

increased pain/temp/uterine tone/ gastric mucus
reduced gastric acid
various effects on vascular smooth muscle and airways

Question 5

Function of thromboxane

Answer 5

increased platelet aggregation
vasoconstriction

Question 6

Function of leukotrienes produced by Arachidonic acid metabolism

Answer 6

Leukotrienes A4, C4, D4, E4 cause bronchoconstriction

B4 causes increased neutrophil chemotaxis

Question 7

What enzyme metabolises Arachidonic acid to form leukotrienes?

Answer 7

Lipoxygenase