Endothelin Flashcards
Action of endothelin
long-acting vasoconstrictor and bronchoconstrictor
What secretes endothelin?
secreted initially as a prohormone by the vascular endothelium
later converted to ET-1 by the action of endothelin converting enzyme.
Endothelin acts via interaction with what type of receptor? What is released via this interaction?
a G-protein linked to phospholipase C leading to calcium release
Endothelin is important in the pathogenesis of many diseases. Give examples
primary pulmonary hypertension (endothelin antagonists are now used)
cardiac failure
hepatorenal syndrome
Raynaud’s.
Factors which promote endothelin release
angiotensin II
ADH
hypoxia
mechanical shearing forces
Factors which inhibit endothelin release
nitric oxide
prostacyclin
Raised levels of endothelin are seen in
primary pulmonary hypertension
myocardial infarction
heart failure
acute kidney injury
asthma
