ARBs Flashcards
What is the action of ARBs?
Binds and inhibits angiotensin II receptors to prevent activation.
What is ARB short for?
Angiotensin II Receptor Blocker
Where do ARBs have their effect?
- Smooth muscles,
- adrenal cortex
Identify the intended effects of ARBs.
- Prevents vasoconstriction, decreases blood pressure.
- Reduced aldosterone production to lower sodium and fluid (potassium sparing).
Identify the uses for ARBs.
Primarily HTN,
Also: heart failure, diabetic nephropathy, post-IM
What presentation of hypertension is contraindicated for ARBs?
ARBs are NOT for acute high BP
Identify contraindications for ARBs.
impaired renal function,
pregnancy, lactation
Identify adverse effects of ARBs.
Angioedema (but less risk that other HTN meds)
headache, dizziness,
syncope, weakness
electrolyte imbalance,
GI complaints
Identify the most common electrolyte imbalance associated with ARBs.
hyperkalemia
Identify the drug interactions of ARBs.
“Spartans didn’t have batteries!”
* lithium toxicity
Things that worsen kidney function or increase potassium:
* K+ sparing diuretics, K+ rich foods, salt substitutes
* NSAIDs
What to assess/teach with ARBs?
- hypovolemia/dehydration
- hyperkalemia (paresthesias)
- labs (K+, renal function)
- low BP
Identify the exemplars for ARBs.
“LoSPARTANS yell ARB!”
Losartan
Do ARBs cause a cough because they act in the lungs?
No, no cough, act outside the lungs.
