Flashcards in Arrhythmias 1 and 2 Deck (125):
What is an arrhythmia?
Abnormality of heart rate or rhythm
What are the 2 broad anatomical types of arrhythmias?
What are the names of the 3 internal tracts that connect the SA node and AV node?
Anterior, middle and posterior internodal tracts
What are ectopic beats?Name when you have several of these in a row?
Beats or rhythms that originate in places other than the SA node (when the latent pacemaker fires at a rate faster than the SA node)Ectopic rhythm - ectopic focus dictates the entire rhythm
Are ectopic beats/ rhythms dangerous?
Depends how the affect the cardiac output
How can arrhythmias be categorised based on rate?
What are the 4 types of atrial tachycardia? (SVT)
Atrial fibrillationAtrial flutterEctopic atrial tachycardiaSinus tachycardia
What are the 2 types of atrial bradycardia?
Sinus bradycardiaSinus pauses
What are the 3 types of atrioventricular node arrhythmias?
AV node re-entryAccessory pathwaysAV block
What are the 4 types of ventricular arrhythmias??
Premature ventricular complexVentricular tachycardiaVentricular fibrillationAsystole
What are the clinical causes of arrhythmias? (5)
Abnormal anatomy e.g. left ventricular hypertrophy, accessory pathwaysAutonomic e.g. sympathetic stimulation (nervousness, hyperthyroidism), increased vagal toneMetabolic e.g. hypoxic myocardium, ischaemic myocardium, electrolyte imbalancesInflammation e.g. viral myocarditis]DrugsGenetics (mutations of cardiac ion channels) e.g. congenital long QT syndrome
What are the 5 mechanisms of arrhythmias?
Defects in impulse formation (altered automaticity, triggered activity)Defects in impulse conduction (re-entry, accessory tracts, conduction block)
What is altered automaticity?
When a latent pacemaker takes over the SA nodes function as the normal pacemaker of the heart (causes escape or ectopic beats) - can occur physiologically when the ANS modulates the SA nods activity e.g. caused by drugs, ischaemia
What is triggered activity?
When abnormal action potentials are triggered by a preceding action potential resulting in the heart cells beating twice e.g. tornadoes de points
What is re-entry?
Self-sustaining electrical circuit stimulates an area of the myocardium to be stimulated repeatedly
What is conduction block?
Any disease that disrupts electrical conduction may reduce conduction or cause heart block
What are accessory pathways?
Additional electrical conduction pathway between 2 areas of the heart e.g. WPW
What effect does hypothermia have on phase 4 of AP slope?
Decreases it (altered automaticity)
What effect does hyperthermia have on phase 4 of action potential slope?
Increases it (altered automaticity)
What effect do hypoxia and hypercapnia have on phase 4 of AP slope?
increase it (altered automaticity)
What effect does hypokalaemia have on phase 4 of AP slope?
Increases it (also prolongs repolarisation and increases ectopics)
Symptoms of arrhythmias?
Palpitations (a noticeably rapid, strong or irregular heart beat)SOBDizinessSyncopeSudden cardiac deathWorsen pre-exisiting conditiosn e.g. angina
Investigations of arrhythmias? (&)
12 lead ECGCXREchocardiogramStress ECG24 hours ECG hotter monitoringEvent recorderElectrophysiological (EP) study
Why is an ECG done for arrhythmias?
To assess rhythmSigns of previous MI, pre-excitation (WPW)
What sign on an ECG suggests a previous MI?
Pathological Q waves
Why perform an exercise ECG in a patient with suspected arrhythmia?
To assess for ischaemiaExercise induced arrhythmia
Why perform a 24 hour hotter ECG in a patient with suspected arrhythmia?
To assess for paroxysmal arrhythmiaTo link symptoms to underlying heart rhythm
Why perform an echo in a patient with suspected arrhythmia?
To assess for structural heart disease
Why perform an electrophysiological study in a patient with a suspected arrhythmia?
To trigger the arrhythmia and study its mechanismOpportunity to treat by ablation at the same time
What are the symptoms of atrial ectopic beats?
Treatment of atrial ectopic beats?
Generally no treatment but patients may find B blockers helps (avoid stimulants e.g. caffeine)
When is sinus bradycardia physiological?
What is sick sinus syndrome?
Sinus node dysfunction causing bradycardia +/- rest, senatorial block, or SVT alternating with bradycardia/ asystole
What are causes of sinus bradycardia?
Drugs e.g. beta blockersIschaemiaLots more
Treatment of sinus bradycardia?
Atropine (if acute, e.g. MI)Pacing if haemodynamic compromise e.g. hypotension, CHF, angina, collapse
Causes of sinus tachycardia?
Physiological in anxiety, fever, hypotension, anaemiaInappropriate due to drugs, etc.
Treatment of sinus tachycardia?
Treat underlying causeB-adrenergic blockers
What is an example of a paediatric vagal manoeuvre (used to treat SVT)?
ice water to face for infantsBlow through straw (valsalva) for child or adolescents
What is the most common cause of SVT?
What causes atrioventricular re-entry anatomically?
A small re-entry circuit involving the atrioventricular node and surrounding atrial tissue
What is wolf-parkinson-white?
Presence of an accessory pathway between the atria na ventricles causing ventricular pre-excitation
What type of abnormality does WPW cause on an ECG?
Acute management of SVT?
Vagal manoeuvresIV adenosine (extremely short half life so have to push it in as fast as you can)IV verapamil
Chronic management of SVT?
Avoid stimulantsRadifrequency ablationAnti-arrhythmic drugs (Class II or IV)
What is cardiac ablation?
Selective cauterisation of cardiac tissue to prevent tachycardia, targeting either an automatic focus or part of a re-entry circuit
What does cardiac ablation involve?
Placement of catheters in heart via femoral veinsIntracardiac ECG recorded during sinus rhythm, tachycardia and during pain manoeuvresCatheter placed over focus/ pathway and tip heated
What causes AV node conduction disease?
Ageing processAcute MIMyocarditisInfiltrative disease e.g. amyloidDrugs e.g. B blcokers, Calcium channel blockersCalcific aortic valve diseasePost-aortic valve diseasesGenetic e.g. Lenore's disease, myotonic dystroph
1st degree heart block?
PR interval prolonged (greater than 0.2 seconds)
Treatment of 1st degree heart block?
None - long term follow up recommended as more advanced block may develop
What are the 2 types of 2nd degree heart block?
Mobitz IMobitz II
What is Mobitz I?
Prolong PR interval cumulating in a droped ventricular beat (QRS complex)
what is Mobitz II?
Regularly more than one P wave to each QRS complex in a 2:1, 3:1 or 4:1 ratio
Treatment of mobitz II?
Treatment of mobitz I?
What is third degree heart block?
Complete atrioventricular dissociation: regular P waves, regular QRS complexes but no association between the 2
Treatment of 3rd degree heart block?
What is trancutaneous pacing?
Using a defibrillator to pace the heart during an emergency (other type is transvenous)
What are the 2 types of pacemakers available?
Single chamber (paces the right atria or right ventricle only)Dual chamber (paces the RA and RV)
What is a single chamber pacemaker used for?
Atrial = isolated SA node disease but normal AV nodeVentricular = AF with slow ventricular rate
What is a dual chamber pacemaker used for?
Maintains AV synchrony - AVN disease
What are premature ventricular complexes?
ectopic impulses originating from an area distal to the His Purkinje system. VPCs are the most common ventricular arrhythmia
What causes premature ventricular complexes?
May not have structural heart diseaseIschaemic heart diseaseHypertension with left ventricular hypertrophyHeart failureMay be marker for inherited arrhythmia syndrome
Symptoms of premature ventricular complexes?
Treatment of premature ventricular ectopics?
What is a broad complex tachycardia in a patient with no history of cardiac disease?
What is ventricular tachycardia?
Tachycardia originating from a ventricular focus
Is VT life threatening?
What type of patients does VT occur in?
Usually those with significant heart disease e.g. coronary artery disease Rarely, cardiomyopathyInherited syndrome e.g. long QT, Brugada syndrome(look for cause of VT .e.g electrolytes (hypokalaemia, hypomagnesaemia, ischaemia, hypoxia, medications)
what is long QT syndrome?
a rare inherited or acquired heart condition in which delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsades de pointes
What is Brugada syndrome?
a genetic disease that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death.
Difference between monomorphic and polymorphic VT?
in mono. QRS = symetricalIn poly. QRS = unsymetrical
What is ventricular fibrillation?
Chaotic ventricular electrical activity which causes the heart to lose the ability to function as a pump
Treatment of VF?
Defibrillation and cardiopulmonary resuscitation
Treatment of VT?
DC cardioversion if unstableIf stable consider pharmacologic cardioversion with AADIf unsure if VT or something else, consider adenosine to make a diagnosis
what long term treatments are available for VT?
Implantable cardiovertor defibralltorsCHF therapies
What is normally the cause of ventricular arrhythmias?
What causes atrial flutter?
rapid heart rate causes by re-entry circuits in the atrium
Appearance of atrial flutter on ECG?
Saw tooth appearance
What is atrial fibrillation caused by physiologically?
Rapid, unsynchronised and chaotic electrical activity which causes conduction of irregular signals to the ventricles due to multiple weavlets of re-entry and ectopic focus around the pulmonary veins
What results in increased R wave amplitude in the left-sided ECG leads (I, aVL and V4-6) and increased S wave depth in the right-sided leads (III, aVR, V1-3)?
Left ventricular hypertrophy
Type of heart beat in A Fib?
What are the 3 different types of AFib?
What is paroxysmal AFib?
Reverts to sinus rhythm spontaneously - often recurrent
What is persistent AFib?
AF that is not self terminating/ has lasted longer than 7 days but can be terminated through treatment
What is permanent AFib?
Continuos AF that cannot be successfully terminated
What does incidence of AFib increase with?
Associated diseases/ causes of AFib?
HypertensionCongestive heart failureSick sinus syndrome - "tachy brady syndrome"Coronary heart diseaseThyroid diseaseFamilialValvular heart diseaseAlcohol abuseCongenital heart diseaseCardiac surgeryOther rarer causes e.g. COPDEither classified into cardiac or non-cardiac cause
What is lone (idiopathic) AFib?
Absence of any underlying cause for AF (diagnosis of exclusion)
Symptoms of AFib?
PalpitationsPre-syncope (dizziness)SyncopeChest painDyspnoeaSweatinessFatigueCan be asymptomaticSymptoms often worse at the onset of AF
Termination of atrial fib?
pharmacological cardioversion with anti-arrhythmic drugs (30% effective)Electrical cardioversion (90% effective)Spontaneous reversion to sinus rhythm
What are the anti-arrhythmic drug examples that can be used to terminate and prevent atrial fib?
ECG of atrial fib?
Atrial rate greater than 300 bpm
Rhythm in Atrial Fib?
Ventricular rate in atrial fib?
Variable (dependent upon AV node conduction properties, sympathetic and parasympathetic tone, presence of drugs which act on the AV node)
Recognition of atrial fib on ECG?
Absence of P waves, presence of f waves - ventricular rate is irregular
What pharmacological agents are useful in controlling ventricular rate in AF by decreasing conduction in the AV node?
Beta blcokersCalcium channel blcokers
Ventricular rate in A fib?
IrregularCan be slow, normal or fast (and ranging between these) - depends on AV node conduction properties, sympathetic and parasympathetic tone, presence of drugs which act on the aV node (e.g. flecanide, sotolol, amiodarone)
What is it called when AF goes so fast that it looks regular but it actually its?
How does AF cause a reduced cardiac output?
Lost atrial kick and decreased killing time
If the patient has hypertrophic cardiomyopathy, what can AFib result in?
Congestive heart failure
What does ventricular rates less than 60bpm in AF suggest?
AV conduction disease
Management of AF?
Rhythm control (maintain SR predominantly)ORRate control: Accept AF but control ventricular rateAnti-coagulation for both approaches if high risk for thromboembolism
Rate control during AFib?
Pharmacological therapy to slow down AVN conduction:DigoxinBetablcokersVerapamil, diltizamGive the above alone or in combinationIf the above doesnt work, the aV node can be completely ablated and a pacemaker fitted
Rhythm control of Afib?
Restoration of NSR:Pharmacological cardioversion (anti-arrhythmic drugs e.g. amiodarone)Direct current cardioversionMaintenance of NSR:Anti-Arrhythmic drugsCatheter ablation of atrial focus/ pulmonary veinsSurgery (Maze procedure)
Treatment of paroxysmal AF?
Rhythm control:Cardiovert (pharma/ DC)Anti-Arrhythmic drugs to preventAnti-coag
Treatment of persistent or permanent AF?
Rate control (digoxin, beta blocker, verapamil or diltiazem)Anti-coagulation if high riskDC cardioversion if structurally normal heart
what is tornadoes de pointes?
a specific form of polymorphic VT in patients with a long QT interval. It is characterized by rapid, irregular QRS complexes, which appear to be twisting around the ECG baseline - it can be acquired or congenital (very deadly form of vt)
Heart rate in torsades de points?
Rhythm in torsades de pointes?
Irregular (In comparison to normal VT)
Recognition of tornadoes de pointes?
Long QT intervalWide QRSContinuously changing QRS morphology
Events leading to Torsdaes de points?
hypokalaemiaProlongation of AP duration (drug induced)Renal impairment (increased drug levels)
What is the scoring system used to assess risk of thromboembolism in atrial fib?
What is the CHADSVASC score
C Congestive heart failure (or Left ventricular systolic dysfunction) 1 H Hypertension: blood pressure consistently above 140/90 mmHg (or treated hypertension on medication) 1 A2 Age ≥75 years 2 D Diabetes Mellitus 1 S2 Prior Stroke or TIA or thromboembolism 2 V Vascular disease (e.g. peripheral artery disease, myocardial infarction, aortic plaque) 1 A Age 65–74 years 1 Sc Sex category (i.e. female sex) 1 Score is 1 maybe antii-cogaulantIf 2 or greater then you should be on anti-coagulants
What puts patients at a high risk of thromboembolism?
Valvular heart diseaseAge greater than 75 especially femaleHypertensionHeart failurePrevious TE/strokeCoronary artery disease or diabetes and greater than 60yoThyrotoxicosis
Indications for anti-coag in AF?
Valvular AF (mitral valve disease)Non valvular AF if:Age greater than 75HypertensionHeart failurePrevious stroke/ thromboembolismCAD/ DMDaibetes
Bleeding risk assessment for AF?
HAS BLEDHypertension 1Abnormal renal or liver function 1 or 2Stroke 1Bleeding 1Labile INRs 1Elderly (age greater than 65) 1Drugs or alcohol 1 or 2(if score is greater than 3 = high risk)
Why type of ablation is done in AF to maintain sinus rhythm?
Ablating AF focus
What type of ablation is done in AF to control rate?
Ablation of AVN to stop fast conduction to the ventricles
Is Atrial flutter regular or irregular?
Regular - usually paroxysmal and is rapid
Where is the re-entry circuit in atrial flutter?
How long can episodes of Atrial flutter last?
Seconds to years
What does chronic atrial flutter usually progress to?
Risk of atrial flutter?
May result in thrombi-embolism
Characteristic feature of Atrial flutter on eCG?
Regular rapid rate with saw root F wave