Arrhythmias Flashcards
(11 cards)
Digoxin
Mechanism of action:
Inhibit Na/K ATPase
Clinical use:
CHF, atrial fibrillatin and flutter
Toxicity:
Arrhythmias, vision
Extra info:
monitor carefully if given with other anticoagulants
Procainamide
Class:
AAD Class 1A
Other:
Quinidine
MOA:
Inhibit of Na
Clinical uses:
IV injection for atrial flutter and fibrillation,, ventricular tachycardia and fibrillation
Toxicity:
Arrhythmias, hypersensitivity reactions (SLE-like symptoms)
Lidocaine
Class:
AAD Class 1B
Other:
Mexiletine
MOA:
Inhibit of Na
ventricular tachycardia
Toxicity:
CNS
Extra info:
DDIs with PPIs
Flecainide
Class:
AAD Class 1C
MOA:
Inhibit Na channels
MOA:
Atrial tachycardia with normal ventricular function,
Toxic:
Arrhythmias
Amoidarone
Class:
Class I/ III
MOA:
Inhibit Na and K channels
Clinical uses:
Atrial and ventricular tachycardia
Toxic:
Long QT, hypotension, pulmonary fibrosis, tissue deposits, drug interaction
Dronaderone
Class:
Class I/III
MOA:
Inhibit of NA/ K channels
Clinical uses:
Atrial and ventricular arrhythmias
Toxicity:
Long QT, depressed conduction
Dofetilide
Class:
Class III
MOA:
Inhibit K channels
Clinical:
Atrial arrhythmia
Toxicity:
Long QT
Sotalol
MOA:
Inhibit K channels and beta-adrenergic receptors
Clinical:
atrial and ventricular arrhythmias
Toxicity: Long QT
Verapamil
Class:
AAD Class IV
Other names:
Diltiazem
MOA:
Voltage gated Ca channel inhibitor, cardiac preferring
Clinical uses:
atrial arrhythmias > angina, HTN
clinical:
hypotension, tachycardia
Nifedipine
Class:
L-type Ca Channel blockers
Other:
Amlodipine, felodpine, nicardipine, nisoldipine, nitrendipine
MOA:
Voltage gated Ca channel inhibitor, VSM preferring
Clinical uses:
Angina, HTN
Toxicity:
Hypotension, tachycardia
Adenosine
MOA:
Activate adenosine receptors –> decreases K in cell–> hyperpolarization –> leading to cardioinversion
Clinical:
conversion of atrial arrhythmias except Atrial fibrillation
