Vascular drugs Flashcards
(18 cards)
Pyridostigmine
reversible inhibitor of AChE
treatment:
neurogenic orthostatic hypotension
myasthenia gravis
Atropine
non-selective muscarinic antagonist
treatment:
reversal of vagal bradycardia
antidote for cholinesterase inhibitor toxicity
Midodrine
alpha 1 agonist
treatment:
chronic orthostatic hypotension
Phenylephrine
alpha 1 agonist
treatment:
test of baroreflex, short-term vasoconstriction, decongestant
Clonidine
alpha 2 agonist (decreases sympathetic tone)
treatment:
HTN
dobutamine
Beta 1/2 and alpha agonist
mostly B1
treatment:
increases CO in acute heart failure
isoproterenol
non selective beta agonist
treatment:
limited uses in bradycardia
dopamine
D1 vasodilation, low doses b1 and lower doses alpha 1
treatment:
shock; sometimes used in heart failure
epinephrine
low doses Beta 2, high doses alpha 1 agonist
treatment:
emergency cardiac arrest, anaphalaxis
norepinephrine
non-selective alpha 1 and beta 1
treatment: restores BP in acute hypotensive states
methyldopa
acts like clonidine… converted to methylnorepiphrine (alpha 2 agonist)
treatment:
limited anti-HTN in pregnancy
doxazosin
alpha 1 antagonist
treatment:
BPH, hypertension (rare)
phentolamine
short acting non-selective alpha antagonist
treatment:
extravasation of adrenergic agonist
phenxybenazime
long acting alpha antagonist
treatment:
pheochromocytoma
labetalol
non-selective beta antagonist and alpha 1 antagonist
beta > alpha
treatment:
HTN
carvedilol
non-selective beta antagonist and alpha 1
more beta than alpha, higher affinity than labetalol
treatment:
HTN, heart failure
metroprolol
beta 1 antagonist
treatment:
HTN
propanolol
non-selective beta antagonist
treatment:
angina, arrhythmia, tremor, stage fright, migraine, headache
