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Flashcards in Arrhythmias Therapy Deck (12)
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1

What is class I of the Vaughan-Williams antiarrhythmic drug classification?

Sodium channel blockers

2

What is the mechanism of action of sodium channel blockers?

Membrane stabilising agents, act principally by suppressing excitability and slowing conduction in atrial or ventricular muscle

3

What are the class Ia drugs? How do they work?

Quinidine
Disopyrmaide

Block sodium channels and prolong AP

4

What are the class Ib drugs? How do they work?

Lidocaine
Mexiletine

Block sodium channels and shorten AP

5

What are the class Ic drugs? How do they work?

Flecanide
Propafenone

Block sodium channels, no effect on AP

6

What is class II of the Vaughan-Williams antiarrhythmic drug classification?

Beta blockers

7

What are the class II drugs?

Atenolol
Bisoprolol
Metoprolol
L-sotalol

Beta-adrenoceptor antagonists

8

What are the class III Vaughan-Williams antiarrhythmic drugs?

Amiodarone
D-sotalol

9

What is the mechanism of action of the class III drugs?

Main effect is to prolong the AP - act by prolonging the plateau phase of the AP, thus lengthening the refractory period

10

What is class IV of the Vaughan-Williams antiarrhythmic drug classification?

Slow calcium channel blockers

11

What are the class IV drugs?

Verapamil
Diltiazem

12

What is the mechanism of action of the class IV drugs?

Block the slow calcium channel which is particularly important for impulse generation and conduction in atrial and nodal tissue