Arthritides

Question 1

Osteoarthritis (OA)

Answer 1

Repeated microtrauma causes chondrocytes to release enzymes that cause further trauma.
Leading cause of chronic disability
Loss of articular cartilage
Older age, female, obese

Question 2

OA Imagine

Answer 2

Joint space narrowing

Surface irregularty

Question 3

Most common joints affected by OA

Answer 3

Hands (70%)
MIddle aged and elderly women
Family hx

Question 4

Which hand joints are affected?

Answer 4

DIP and PIP

Question 5

Heberdons nodes

Answer 5

DIP

Question 6

Bouchards nodes

Answer 6

PIP

Question 7

Rheumatois Arthritis (RA)

Answer 7

Most common inflammatory arthritis.1% of pop, mostly women in 40s and 50s.

Question 8

RA involves which part of the joint?

Answer 8

The synovium

Leads to cartilage loss and bone erosion

Question 9

RA S/S

Answer 9

Gradual, insidious onset
Pain, stiffness, swelling
Sx wax and wane
Symmetrical, bilateral

Question 10

RA imaging

Answer 10

Joint space narrowing
Soft tissue swelling
Bony erosions

Question 11

RA Hand

Answer 11

Swollen, painful MP and PIP joints.

Joint deformities, swan neck

Question 12

Most common site for RA of upper extremity?

Answer 12

Wrist

Question 13

Shoulder and Hips present early or late?

Answer 13

Late

Question 14

Gouty Arthritis

Answer 14

Crystalline Arthropathy
Red, hot, swollen and painful joint.
Skin is sensitive
Pain develops over 2-4 hrs, usually at night

Question 15

Gout MOA

Answer 15

Disorder of purine metabolism
Hyperuricemia
Crystals provoke inflammatory rxn

Question 16

Pseudogout

Answer 16

CPPD
Calcium pyrophosphate dehydrate dz
Crystals deposited in joints

Question 17

Gout and pseudogout commonly affect the?

Answer 17

Big toe

Question 18

RA Tx

Answer 18

NSAIDS
Systemic steroids
Methotrexate, arava, humira

Question 19

Gout Tx

Answer 19

NSAIDS
Colchine
Glucocorticoids
Allopurinol