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Rheumatology > Pharm > Flashcards

Pharm Flashcards

1
Q

Glucorticoid MOA

A

Block IL-1 and IL-2
Inhibition of proinflamatory mediators
Decrease leukocyte adherance to vascular endothelium.
Decreased APC’s

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2
Q

Main infxns w/ long-term steroid therapy?

A

Herpes zoster
Staph
Candida

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3
Q

Monitoring for GC use

A 
BP
Glucose
Lipids
Eye exam
Bone density
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4
Q

RA GC Use

A

Good for quick sx relief

Do not have profound effect on bone destruction

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5
Q

1st line for mild RA

A

Hydroxychloroquine

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6
Q

1st line for mild RA w/ poor prognostic factors

A

Methotrexate

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7
Q

1st line for moderate to severe RA

A

MTX (methotrexate)

Takes 3-6 months

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8
Q

Hydroxychloroquine (Plaquenil)

A

Antimalarial
Does not limit progress of RA
2-6 months for response
Used as single agent for mild RA or an add of to MTX for severe dz.

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9
Q

Hydroxychloroquine (Plaquenil) SE

A 
Macular toxicitiy (fundo exam) bulls-eye maculopathy
GI sx
Rash, pigment changes.
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10
Q

Sulfasalazine (Azulfidine)

A

Inhibit PMN migration
Reduced lymphocyte response
Decrease inflammation

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11
Q

Methotrexate (Rheumatrex)

A

Most commonly used drug for RA
Structural analog of folic acid
Need supplemental folic acid

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12
Q

Rheumatrex dosing

A

Weekly

Daily will cause hepatotoxicity

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13
Q

MTX monitoring

A 
Every 1-2 months
CBC
LFT
Albumin
Creatinine
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14
Q

TNF inhibitors

A

Etanercept (Enbrel)
Infliximab (Remicade)
Adalimumab (Humira)

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15
Q

TNF inhibitors cause reactivation of?

A

TB

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16
Q

Leflunomide (Avara)

A

SImilar to MTX

Inhibits pyrimidine synth

17
Q

Leflunomide (Avara) CI

A

Pregnancy

Anything liver

18
Q

Anakinra (Kineret)

A

IL-1 receptor aognist

Decreases destruction and inflammation.

19
Q

Meds that make SLE worse

A

Sulfa containing abx
Minocycline
BCP

20
Q

Lupus antimalarial tx

A

Hydroxychloroquine
May prevent damage
Works for both types

21
Q

Other lupus tx

A

Glucocorticoids

MTX

22
Q

If antiphosphilipid antibody positive SLE?

A

Lifelong warfarin

INR of 2-3

23
Q

Acute gout attack tx

A

1: NSAIDS
2: Colchicine
3: Steroids

24
Q

Gout prevention

A

Allopurinol

25
Q

Gout NSAIDS

A

Indomethican
Naproxen
Celebrex

26
Q

How long to wait after gout attack to start prevention therapy?

A

2 weeks

27
Q

Probenecid

A

2nd line for gout

Lots of dug interactions

Rheumatology (7 decks)

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