AS additional info

Question 1

Neurotrophic Arthropathy- what is it?

Answer 1

Aka Charcots joints
Degenerative arthritis secondary to vascular or neural deficiency
Non-painful and there is complete destruction
diabetic and syphillis patients

Question 2

Clinical features of Charcot joint

Answer 2

Altered gait patterns
Joint enlargement and crepitus
Painless instability of affected joint

Question 3

6 D’s of charcot joints

Answer 3

Density of subchondral sclerosis
Destruction of bone
Debrid in the joint
Dislocation 
Disorganisation of joint elements
Distension of joint

Question 4

Synovial effects of AS

Answer 4

pannus forms over articular cartilage and erodes it and the subchondral bone
Pannus becomes fibrotic and becomes cartilage/ bone producing tissue which leads to ankylosis

Question 5

Cartilage effects of AS

Answer 5

subchondral osteitis: Inflammatory cells and granulation tissue invade bone
fibrous tissue replaces the bone
fibrous tissue ossifies

Question 6

Enthesis in AS

Answer 6

Normal entheses gradually transition from fibrous stissue to cartilage to calcifief cartilage to bone
formation of syndesmophytes as the bone repairs where the ST once was