Asthma Flashcards
(22 cards)
What is the aetiology of asthma
Reversible obstructive airway characterised by intermittent inflammation, periods of wheezing and chest tightness
How do you diagnose asthma
One or more symptoms (wheezing, cough, breathlessness and chest tightness)
Family history
FEV1/FVC < 70%
PEF greater than 20%
Define controlled asthma
No daytime symptoms
No nighttime waking
No need for rescue meds
No asthma attacks
Normal lung function
What does clenil modulate contain?
Beclometasone
What does flixotide contain
Fluticasone
What does frost air contain (FB)
Formoterol and beclometasone
What does Seretide contain (FS)
Salmeterol and Fluticasone
What does symbicort contain? (FB)
Formoterol and budesonide
What does spirits contain
Tiotropium
What does incruse ellipta contain
Umeclidinium
What does Trimbow contain (BFG)
Formoterol, belcometasone, glycopyrronium
What does trelegy ellipta contain (FUV)
Vilanterol, Fluticasone, Umeclidinium
Give an example of LTRA’s
Montelukast
Give 4 examples of inhaled corticosteroids
Beclometasone, Fluticasone, budesonide, mometasone
Name 3 xanithes
Theophylline, theobromine, aminophylline
Name a SAMA
Ipratropium
Name 3 LAMAs
Tiotropium, Umeclidinium, glycopyrronium
MOA of beta agonists
Activating beta receptors in smooth muscle. Generating more cAMP, which activates protein kinase that removes calcium from the cell causing relaxation
MOA of xanithes
Inhibits phosphodiesterases responsible for cAMP breakdown. Causing bronchodilation
What increases and decreases the plasma concentration of theophylline
Hear failure and renal impairement increases the conc
Alcohol and smoking decreases the coco
MOA of muscarinic receptor antagonists
Increases airflow by blocking cholinergic tone and vasoconstriction caused by the vagus nerve. Inhibits mucus production
MOA corticosteroids
Reduce frequency and severity of asthma attacks. Reduces inflammatory cell activity and release of cytokines. Inhibiting arachidonic acid release to reduce IL production
