Asthma

Question 1

What is the aetiology of asthma

Answer 1

Reversible obstructive airway characterised by intermittent inflammation, periods of wheezing and chest tightness

Question 2

How do you diagnose asthma

Answer 2

One or more symptoms (wheezing, cough, breathlessness and chest tightness)
Family history
FEV1/FVC < 70%
PEF greater than 20%

Question 3

Define controlled asthma

Answer 3

No daytime symptoms
No nighttime waking
No need for rescue meds
No asthma attacks
Normal lung function

Question 4

What does clenil modulate contain?

Answer 4

Beclometasone

Question 5

What does flixotide contain

Answer 5

Fluticasone

Question 6

What does frost air contain (FB)

Answer 6

Formoterol and beclometasone

Question 7

What does Seretide contain (FS)

Answer 7

Salmeterol and Fluticasone

Question 8

What does symbicort contain? (FB)

Answer 8

Formoterol and budesonide

Question 9

What does spirits contain

Answer 9

Tiotropium

Question 10

What does incruse ellipta contain

Answer 10

Umeclidinium

Question 11

What does Trimbow contain (BFG)

Answer 11

Formoterol, belcometasone, glycopyrronium

Question 12

What does trelegy ellipta contain (FUV)

Answer 12

Vilanterol, Fluticasone, Umeclidinium

Question 13

Give an example of LTRA’s

Answer 13

Montelukast

Question 14

Give 4 examples of inhaled corticosteroids

Answer 14

Beclometasone, Fluticasone, budesonide, mometasone

Question 15

Name 3 xanithes

Answer 15

Theophylline, theobromine, aminophylline

Question 16

Name a SAMA

Answer 16

Ipratropium

Question 17

Name 3 LAMAs

Answer 17

Tiotropium, Umeclidinium, glycopyrronium

Question 18

MOA of beta agonists

Answer 18

Activating beta receptors in smooth muscle. Generating more cAMP, which activates protein kinase that removes calcium from the cell causing relaxation

Question 19

MOA of xanithes

Answer 19

Inhibits phosphodiesterases responsible for cAMP breakdown. Causing bronchodilation

Question 20

What increases and decreases the plasma concentration of theophylline

Answer 20

Hear failure and renal impairement increases the conc
Alcohol and smoking decreases the coco

Question 21

MOA of muscarinic receptor antagonists

Answer 21

Increases airflow by blocking cholinergic tone and vasoconstriction caused by the vagus nerve. Inhibits mucus production

Question 22

MOA corticosteroids

Answer 22

Reduce frequency and severity of asthma attacks. Reduces inflammatory cell activity and release of cytokines. Inhibiting arachidonic acid release to reduce IL production