Asthma

Question 1

list all SABA

Answer 1

salbutamol + terbutaline

Question 2

what does SABA stands for

Answer 2

short-acting beta agonist

Question 3

what type of beta receptor does the SABA and LABA target

Answer 3

beta-2

Question 4

what kind of intercelluar recetions it triggers

Answer 4

increase the conversion of ATP to cAMP
upregulate the PKA level—pull the ca2+ back to the SR
overall-bronchodilation

Question 5

all long beta receptor end with

Answer 5

terol

Question 6

can low dose budesonide and formoterol act as reliver Y/N

Answer 6

Y

Question 7

adverse effect of SABA

Answer 7

tremor

Question 8

why overuse of SAMA

Answer 8

down regulate the num of the receptor

Question 9

why for some ppl overuse SABA does not lead to severe consequence

Answer 9

polymorphism

Question 10

can LABA be used by its own ? Y/N

Answer 10

N

Question 11

describe the symbiotic effect of LABA and ICS

Answer 11

ICS could upregulate the effet

Question 12

list SAMA

Answer 12

ipratropium

Question 14

describe how M2 is different from M3

Answer 14

M3 only presents in the post synaptic area while M2 receptor presents in both pre and post synaptic areas and has opposite effect

Question 15

describe how muscarinic receptor causes bronchoconstriction

Answer 15

PKC—stimulate the release of Ca2+ from the SR—increase the intracelluar Ca2+ level

Question 16

theophyline is a

Answer 16

phosphodiesterase inhibitor

Question 17

how phosphodiesterase inhibitor casues bronchodilation

Answer 17

increase cAMP level

Question 18

is ipratropium a SAMA or LAMA

Answer 18

SAMA

Question 19

SAMA is more beneficial than SABA in asthma management Y/N

Answer 19

N

Question 20

is tiotropium a SAMA or LAMA

Answer 20

LAMA

Question 21

tiotropium can be used as a add-on

Question 22

what’s conclude in a triple therapy

Question 23

aspirin-induced repiratory diseases are more prne to happen among patients wiht severe asthma _ naasl poly + chronoc rtY/N

Answer 23

Y

Question 24

mechanism of action of MgSO4

Answer 24

inhibit Ca2+ influx
inhibit histamine release from the mast cell
Ach release from cholinergic receptor
increase the affinity of beta-2 receptor

Question 25

good asthma control

Answer 25

day time sx < 2 days / wk no sx when walking or at night no limitation to the activities need reliver < 2 / wk

Question 26

asthma management for 1-5 yrs

Answer 26

SABA ICS / Montelukast + SABA ICS (higher dose) & ICS / montelukast + SABA

Question 27

asthma management for 6-11 yrs

Answer 27

SABA ICS / Montelukast + SABA ICS (higher dose) & ICS / montelukast & ICS / LABA +SABA

Question 28

asthma > 12

Answer 28

SABA ICS / SABA & budesonide+ fermoterol (as needed_ ICS / LABA (low dose-daily and as needed) & ICS/ LABA (daily) SABA as needed increase the dose

Question 29

phenotypes of asthma

Answer 29

Th2 high and Th2 low

Question 30

IL produced by Th2 cells

Answer 30

IL-5---recruit eosinophils IL4 / IL-13---mast cells

Question 31

features of Th2 high asthma

Answer 31

increased eosinophis level could be slightly prone to have more inflammation feature

Question 32

terbutaline is PBS listed only when the salbutamol is not appropriate for the patient Y/N

Answer 32

Y