Asthma Patho

Question 1

In what phase (early or late) does the activation of IgE occur in asthma pathogenesis?

Answer 1

early

Question 2

What does IgE trigger?

Answer 2

mast cells
macrophages

Question 3

What does IgE activation induce?

Answer 3

-bronchoconstriction
-mucus secretion
-airway edema

Question 4

Which inflammatory cytokines prolong the survival of eosinophils?

Answer 4

IL-5 and GM-CSF

Question 5

Which type of T-helper cell predominates in asthma patients?

Answer 5

TH-2

Question 6

Which type of inflammatory cells play a role in EIB AND bronchial hyperresponsiveness?

Answer 6

MAST CELLS

Question 7

What are alveolar macrophages?

Answer 7

-engulf/digest bacteria
-in large and small airways
-release cytokines and ROS
-amplify inflammatory process

Question 8

From which type of cell is histamine released from?

Answer 8

mast cells

Question 9

Which type of parasympathetic receptor innervates the airway smooth muscle?

Answer 9

M3

Question 10

Which type of sympathetic receptor innervates the airway smooth muscle?

Answer 10

Beta 2

Question 11

What is vasoactive intestinal peptide (VIP)?

Answer 11

-inhibitory neurotransmitter
-helps bronchodilator
-is broken down by peptidases produced by inflammatory cells