Asthma Pharmacology Flashcards
(27 cards)
What is the age indication for ciclesonide?
≥12 years
What is the age indication for fluticasone propionate?
≥4 years
What is the age indication for fluticasone furoate? (Arnuity Ellipta)
≥ 5 years
True or false: Airsupra (Budesonide/Albuterol) can be used for maintenance therapy
FALSE; rescue therapy only
What is the onset of action of salmeterol?
30-60 mins
What is the onset of action of formoterol?
within 3 mins
What is the onset of action of vilanterol?
~15 mins
What is the boxed warning for LABAs?
-increased risk of death in patients when used as MONOTHERAPY in patients with asthma
What is the age indication for Advair (flut propionate/salmeterol)?
≥ 12 years
In what age should DPIs be avoided?
children < 4 years
Which type of device should always be shaken?
MDIs
Which device should be avoided in those with milk protein allergies?
DPI
Which agents are LAMAs?
tiotropium
Which agents are LTRAs?
-montelukast
-zafirlukast
-zileuton
What indications is montelukast approved for?
-allergies
-prevention of EIB
When should montelukast be taken before exercise if used for EIB?
≥ 2 hours before exercise
What are the most common ADR for montelukast?
-HA
-GI side effects
-URI
-PSYCHIATRIC CHANGES: MOOD, DEPRESSION, SUICIDAL THOUGHTS
What is the CI for Zafirlukast?
hepatic impairment
What are the DDIs of Zafirlukast?
-warfarin
-aripiprazole
-theophylline
What are the DDIs of Zileuton?
-ramelteon
-ergot alkaloids
-theophylline
The effects of theophylline (in terms of ADR) are similar to ____.
caffeine:
-HA
-loose stool
-nausea
-tremor
-tachycardia
What is the MOA of theophylline?
-PDE III and PDE IV inhibitor
-increases the force of contraction of diaphragm muscles
In what patients should we use caution is using theophylline?
-CVD
-hyperthyroidism
-PUD
-seizures
What is the target concentration of theophylline?
5-15
