Astroviridae Flashcards
1
Q
general
A
nonenveloped, 5-6 pointed stars on surface
2
Q
genome
A
single linear (+)ssRNA
3
Q
disease
A
astrovirus enteritis
4
Q
transmission
A
fecal-oral
5
Q
hosts
A
self limiting, mild enteritis in calves, lambs, piglets, puppies, kittens, and human
6
Q
pathogenesis in calves
A
virus destroys dome M cells (overlies peyer’s patches) and absorptive enterocytes, resulting in watery diarrhea
germinal centers of underlying lymphoid tissue becomes depleted
7
Q
pathogenesis in lambs
A
mature enterocytes of villi are affected, causing stunting and fusion
8
Q
CS in other hosts
A
diarrhea, dehydration, vomiting, abdominal pain
