Calciviridae Flashcards

1
Q

get their name from calix meaning

A

cup, b/c it has 32 cup shaped surface depressions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

general

A

nonenveloped, icosahedral, linear ssRNA

genomic RNA is infectious

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

replication

A

cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Feline Calicivirus (FCV)

A

highly infectious pathogen of cats

genus: vesivirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Clinical syndromes

A

range from inapparent infections to typically mild or acute oral and upper resp. tract disease in cats
some strains induce lameness (limping syndrome)
highly virulent forms (FCV-VSD) emerged (USA)- systemic infection that is frequently fatal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

FCV pathogenesis

A

virus shed in oral, nasal and conjunctival secretions

transmission largely by direct contact (ingestion, inhalation, conjunctiva)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Main site of replication

A

oral and resp. tissues
strains vary in their tissue tropisms and pathogenicity
can be found in feces and urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CS FCV

A

tongue ulcers (most prominent lesions)
sloughing oral ulcers and rhinitis
chronic ulcerative proliferative gingivostomatitis (possibly immune mediated reaction)
tongue ulcerative glossitis
pneumonia (acute exudative followed by proliferative intersitial pneumonia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Limping syndrome (associated lameness)

A

acute synovitis, thickening of synovial membrane and increased amount of synovial fluid in joint

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

FCV-VSD virulent systemic disease

A

mortality rates as high as 50%
epizootics in USA, recently in europe
vaccinated cats have been affected suggesting that current vaccines may not protect against FCV-VSD
sign. difference from classical disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

mechanisms of FCV-VSD

A

unclear, possible factors:
virus mutations
host and immune factors
environmental and management factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

FCV-VSD pathology

A

ulceration of tongue, gingiva, hard palate, nasal cavity, pinnae, and haired skin
mild hyperemia to sloughing of the entire foot pad
broncho-interstitial pneumonia and necrosis of the iver, spleen and pancrease
infection of endothelial cells, resulting in vascular injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

FCV-VSD clinical signs

A

pyrexia, subcutaneous facial and limb edema, crusted lesions, ulcers and alopecia on nose, lips, and ear, around eyes, and on footpads, anorexia, jaundice, alopecia, resp. distress, epistaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Vesicular exanthema of swine (VES)

A

acute, highly infectious
characterized by fever and formation of vesicles on snout, oral mucosa, soles of feet, coronary band and between toes
lameness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

VES is indistinguishable from

A

foot and mouth disease
vesicular stomatitis
swine vesicular disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Is VES present in the USA?

A

No, it was declared free of VES in 1959