Autacoids

Question 1

Chlorpheniramine

Answer 1

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

Question 2

Cyclizine

Answer 2

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

Question 3

Diphenhydramine

Answer 3

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

Question 4

Dimenhydrinate

Answer 4

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

Question 5

Hydroxyzine

Answer 5

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

Question 6

Meclizine

Answer 6

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

Question 7

Promethazine

Answer 7

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

Question 8

Fexofenadine

Answer 8

2nd Gen H1 receptor antagonist

Allergic rhinitis & utricaria

Question 9

Loratidine

Answer 9

2nd Gen H1 receptor antagonist

Allergic rhinitis & utricaria

Question 10

Cetirizine

Answer 10

2nd Gen H1 receptor antagonist

Allergic rhinitis & utricaria

Question 11

Cimetidine

Answer 11

H2 receptor antagonist

Reduce gastric acid secretion. Treat ulcers, GERD

AE: headache, dizziness, diarrhea, constipation, muscle pain, confusion, hallucinations

Specific to Cimetidine: anti-androgenic effects, CP450 inhibition.

Question 12

Ranitidine

Answer 12

H2 receptor antagonist

Reduce gastric acid secretion. Treat ulcers, GERD

AE: headache, dizziness, diarrhea, constipation, muscle pain, confusion, hallucinations

Question 13

Famotidine

Answer 13

H2 receptor antagonist

Reduce gastric acid secretion. Treat ulcers, GERD

AE: headache, dizziness, diarrhea, constipation, muscle pain, confusion, hallucinations

Question 14

Nizatidine

Answer 14

H2 receptor antagonist

Reduce gastric acid secretion. Treat ulcers, GERD

AE: headache, dizziness, diarrhea, constipation, muscle pain, confusion, hallucinations

Question 15

Cromolyn

Answer 15

Histamine Release Inhibitor

Question 16

Nedocromil

Answer 16

Histamine Release Inhibitor

Question 17

Sumatriptan

Answer 17

5-HT 1D/1B receptor agonist

First line for acute severe migraine attacks.

Contraindicated in patients with CAD or angina due to coronary vasospasm.

Question 18

Metoclopramide

Answer 18

5-HT4 receptor agonist

Prokinetic (helps poop), anti-emetic

AE: Somnolence, nervousness, dystonia. Rarely: extrapyramidal effects.

Question 19

Cisapride

Answer 19

5-HT4 receptor agonist

Prokinetic (helps poop)

No longer available due to severe cardiac AE.

Question 20

Cyproheptadine

Answer 20

5-HT2 receptor antagonist + H1 antagonist

Treat allergic rhinitis, vasomotor rhinitis, manage serotonin syndrome

Question 21

Ondansetron

Answer 21

5-HT3 receptor antagonist

Anti-emetic. Used for nausea & vomiting associated with chemotherapy.

Question 22

Ergotamine

Answer 22

Ergot Alkaloid

Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors.

Used to treat migraine pain.

Question 23

Dihydroergotamine

Answer 23

Ergot Alkaloid

Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors.

Used to treat migraine pain.

Question 24

Bromocriptine

Answer 24

Ergot Alkaloid

Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors.

Used to treat prolactinemia.

Question 25

Cabergoline

Answer 25

Ergot Alkaloid Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors. Used to treat prolactinemia.

Question 26

Ergonovine

Answer 26

Ergot Alkaloid Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors. Used to treat post-partum hemorrhage & diagnose variant angina via provocative test.

Question 27

Methylergonovine

Answer 27

Ergot Alkaloid Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors. Used to treat post-partum hemorrhage.

Question 28

Misoprostol

Answer 28

Eicosanoid (PGE1 analog) Peptic ulcer prevention. Abortifacent with mifepristone or methotrexate.

Question 29

Dinoprostone

Answer 29

Eicosanoid (PGE2) Ripen cervix near term. Abortifacent.

Question 30

Alprostadil

Answer 30

Eicosanoid (PGE1) Maintain ductus arteriosus. Treat impotence.

Question 31

Epoprostenol

Answer 31

Eicosanoid (PGI2) Treat severe pulmonary hypertension. Prevent platelet aggregation in dialysis machines.

Question 32

Latanoprost

Answer 32

Eicosanoid (PGF2a derivative) Treat glaucoma.

Question 33

Zileuton

Answer 33

Leukotriene inhibitor Inhibits 5-lypoxygenase

Question 34

Zafirlukast

Answer 34

Leukotriene inhibitor LTD4 receptor antagonist

Question 35

Montelukast

Answer 35

Leukotriene inhibitor LTD4 receptor antagonist

Question 36

Aspirin

Answer 36

Irreversible nonselective COX inhibitor Prototype salicylate. Treat Kawasaki in pediatrics, prophylaxis of colon cancer. Contraindicated for gout.

Question 37

Diclofenac

Answer 37

Nonselective COX inhibitor

Question 38

Ibuprofen

Answer 38

Nonselective COX inhibitor

Question 39

Indomethacin

Answer 39

Nonselective COX inhibitor DOC for closure of ductus arteriosus in premature infants. NSAID of choice to treat acute gout attacks.

Question 40

Ketorolac

Answer 40

Nonselective COX inhibitor

Question 41

Naproxen

Answer 41

Nonselective COX inhibitor Least cardiac toxicity of any NSAID

Question 42

Piroxicam

Answer 42

Nonselective COX inhibitor

Question 43

Celecoxib

Answer 43

COX-2 selective inhibitor

Question 44

Meloxicam

Answer 44

COX-2 selective inhibitor Less selective than Celecoxib and therefore safer for heart

Question 45

Acetaminophen

Answer 45

Weak COX-1 and 2 inhibitor No significant anti-inflammatory or anti-platelet effects