Autoantibodies

Question 1

Anti-ACh receptor

Answer 1

Myasthenia gravis

Question 2

Anti-basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anticardiolipin, lupus coagulant

Answer 3

• SLE
• Antiphospholipid syndrome

Question 4

Anti-dsDNA

Answer 4

SLE (nephritis)

Question 5

Anti-Smith

Answer 5

SLE

Question 6

Anti-glutamic acid decarboxylase (GAD-65)

Answer 6

DM type 1

Question 7

Anti-hemidesmosome

Answer 7

Bullous pemphigus

Question 8

Anti-histone

Answer 8

Drug-induced lupus

Question 9

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 9

• Polymyositis
• Dermatomyositis

Question 10

Antimicrosomal (anti-TPO)

Answer 10

Hashimoto’s thyroiditis

Question 11

Antimitochondrial

Answer 11

Primary biliary cirrhosis

Question 12

Antinuclear antibodies

Answer 12

SLE (non-specific)

Question 13

Anti-parietal cells

Answer 13

Pernicious anemia

Question 14

Anti-Scl-70 (anti-DNA topoisomerase I)

Answer 14

Diffuse scleroderma

Question 15

Anti-smooth msucle

Answer 15

Autoimmune hepatitis

Question 16

Anti-SSA (anti-Ro)

Answer 16

Sjogren syndrome

Question 17

Anti-SSB (anti-La)

Answer 17

Sjogren syndrome

Question 18

Anti-TSH receptor

Answer 18

Graves disease

Question 19

Anti-U1 RNP (ribonucleoprotein)

Answer 19

Mixed connective tissue disease

Question 20

IgA anti-endomysial (anti-tissue transglutaminase)

Answer 20

Celiac disease

Question 21

Anti-gliadin

Answer 21

Celiac disease

Question 22

MPO-ANCA

Answer 22

• Microscopic polyangiitis
• Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

Question 23

PR3-ANCA

Answer 23

Granulomatosis with polyangiitis (Wegener)

Question 24

IgM antibody that targets IgG Fc region

Answer 24

Rheumatoid arthritis (rheumatoid factor)

Question 25

Anti-CCP/anti-citrullinated protein antibodies (ACPA)

Answer 25

Rheumatoid arthritis

Question 26

Anti-desmoglein

Answer 26

Pemphigus vulgaris

Question 27

Anti-centromere

Answer 27

CREST scleroderma

Question 28

Myasthenia gravis

Answer 28

Anti-ACh receptor

Question 29

Goodpasture syndrome

Answer 29

Anti-basement membrane

Question 30

- SLE - Antiphospholipid syndrome

Answer 30

Anticardiolipin, lupus coagulant

Question 31

SLE (nephritis)

Answer 31

Anti-dsDNA

Question 32

SLE

Answer 32

Anti-Smith

Question 33

DM type 1

Answer 33

Anti-glutamic acid decarboxylase (GAD-65)

Question 34

Bullous pemphigus

Answer 34

Anti-hemidesmosome

Question 35

Drug-induced lupus

Answer 35

Anti-histone

Question 36

- Polymyositis - Dermatomyositis

Answer 36

Anti-Jo-1, anti-SRP, anti-Mi-2

Question 37

Hashimoto's thyroiditis

Answer 37

Antimicrosomal (anti-TPO)

Question 38

Primary biliary cirrhosis

Answer 38

Antimitochondrial

Question 39

SLE (non-specific)

Answer 39

Antinuclear antibodies

Question 40

Pernicious anemia

Answer 40

Anti-parietal cells

Question 41

Diffuse scleroderma

Answer 41

Anti-Scl-70 (anti-DNA topoisomerase I)

Question 42

Autoimmune hepatitis

Answer 42

Anti-smooth msucle

Question 43

Sjogren syndrome

Answer 43

- Anti-SSA (anti-Ro) - Anti-SSB (anti-La)

Question 44

Graves disease

Answer 44

Anti-TSH receptor

Question 45

Mixed connective tissue disease

Answer 45

Anti-U1 RNP (ribonucleoprotein)

Question 46

Celiac disease

Answer 46

- IgA anti-endomysial (anti-tissue transglutaminase) - Anti-gliadin

Question 47

Microscopic polyangiitis

Answer 47

MPO-ANCA

Question 48

Granulomatosis with polyangiitis (Wegener)

Answer 48

PR3-ANCA

Question 49

Rheumatoid arthritis

Answer 49

- IgM antibody that targets IgG Fc region (Rheumatoid factor) - Anti-CCP/anti-citrullinated protein antibodies (ACPA)

Question 50

Pemphigus vulgaris

Answer 50

Anti-desmoglein

Question 51

CREST scleroderma

Answer 51

Anti-centromere

Question 52

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

Answer 52

MPO-ANCA

Question 53

Anti-thyroglobulin

Answer 53

- Hashimoto - Graves