Autoantibodies

Question 1

Myasthenia Gravis

Answer 1

Anti-ACh receptor

Question 2

Goodpasture syndrome

Answer 2

Anti-basement membrane

Question 3

SLE, Antiphospholipid syndrome

Answer 3

Anti-cardiolipin, lupus anticoagulant

Question 4

Limited Scleroderma (CREST syndrome)

Answer 4

Anticentromere

Question 5

Pemphigus Vulgaris

Answer 5

Anti-desmoglein

Question 6

SLE

Answer 6

Anti-dsDNA, anti-Smith

Question 7

Type 1 Diabetes Mellitus

Answer 7

Anti-glutamate decarboxylase (GAD-65)

Question 8

Bullous pemphigoid

Answer 8

Anti-hemidesmosome

Question 9

Drug-induced lupus

Answer 9

Antihistone

Question 10

Polymyositis, dermatomositis

Answer 10

Anti-Jo1, anti-SRP, anti-MI-2

Question 11

Hashimoto Thyroiditis

Answer 11

Antimicrosomal, antithyroglobulin

Question 12

Primary biliary cirrhosis

Answer 12

Antimitochondrial

Question 13

SLE, nonspecific

Answer 13

Antinuclear antibodies

Question 14

Scleroderma (diffuse)

Answer 14

Anti-Scl-70 (anti DNA topoisomerase I)

Question 15

Autoimmune hepatitis

Answer 15

Anti-smooth muscle

Question 16

Sjogren syndrome

Answer 16

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Question 17

Grave Disease

Answer 17

Anti-TSH Receptor

Question 18

Mixed Connective Tissue Disease

Answer 18

Anti-U1 RNP (ribonucleoprotein)

Question 19

Granulomatous with Polyangiitis (Wegener)

Answer 19

c-ANCA (PR3-ANCA)

Question 20

Celiac Disease

Answer 20

IgA antiendomysial, IgA anti-tissue transglutaminase

Question 21

Microscopic polyangiitis, Churg-Strauss Syndrome

Answer 21

p-ANCA (MPO-ANCA)

Question 22

Rheumatoid Arthritis

Answer 22

Rheumatoid factor (Ab, most commonly IgM, specific to IgG Fc region), anti-CCP