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Autoantibodies Flashcards

(33 cards)

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1
Q

Anti-ACh receptor

A

Myasthenia Gravis

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2
Q

Anti-basement membrane

A

Goodpasture syndrome

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3
Q

Anticardiolipin, lupus anticoagulant

A

SLE, antiphospholipid syndrome

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4
Q

Anticentromere

A

Limited scleroderma (CREST syndrome)

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5
Q

Anti-desmoglein (Anti-desmosome)

A

Pemphigus vulgaris

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6
Q

Anti-dsDNA, anti-Smith

A

SLE

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7
Q

Anti-glutamic acid decarboxylase (GAD-65)

A

Type I DM

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8
Q

Antihemidesmosome

A

Bullous pemphigoid

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9
Q

Anti-histone

A

Drug-induced lupus

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10
Q

Anti-Jo-1, Anti-SRP, Anti-Mi-2

A

Polymyositis, dermatomyositis

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11
Q

Antimicrosomal, Antithyroglobulin

A

Hashimoto thyroiditis

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12
Q

Antimitochondrial

A

Primary biliary cirrhosis

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13
Q

Antinuclear (ANA)

A

SLE, nonspecific

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14
Q

Antiparietal cell

A

Pernicious anemia

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15
Q

Antiphospholipase A2 receptor

A

Primary membranous nephropathy

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16
Q

Anti-Scl-70 (Anti-DNA topoisomerase I)

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A

Scleroderma (diffuse)

17
Q

Anti-smooth muscle

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A

Autoimmune hepatitis type I

18
Q

Anti-SSA, Anti-SSB (Anti-Ro, Anti-La)

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A

Sjogren syndrome

19
Q

Anti-TSH receptor

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A

Graves disease

20
Q

Anti-U1 RNP (ribonucleoprotein)

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A

Mixed connective tissue disease

21
Q

Voltage-gated calcium channel antibodies

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A

Lambert-Eaton syndrome

22
Q

IgA Anti-endomysial, IgA Anti-tissue transglutaminase

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A

Celiac disease

23
Q

MPO-ANCA/p-ANCA

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A

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

24
Q

PR3-ANCA/c-ANCA

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A

Granulomatosis with polyangiitis (Wegener’s syndrome)

25
Rheumatoid factor (IgM antibody that targets IgG Fc region), Anti-CCP (more specific)
Rheumatoid arthritis
26
HLA-A3
Hemochromatosis
27
HLA-B8
Addison disease, myasthenia gravie
28
HLA-B27
Psoriatic arthritis, Ankylosing spondylitis, IBD-associated arthritis, Reactive arthritis (Reiter's syndrome)
29
HLA-DQ2/DQ8
Celiac disease
30
HLA-DR2
Multiple sclerosis, hay fever, SLE, Goodpasture syndrome
31
HLA-DR3
Diabetes mellitus type I, SLE, Graves disease, Hashimoto thyroiditis, Addison disease
32
HLA-DR4
Rheumatoid arthritis, Diabetes mellitus type I, Addison disease
33
HLA-DR5
Pernicious anemia --> Vitamin B12 deficiency, Hashimoto thyroiditis

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