Autoantibodies Flashcards

1
Q

Anti-Scl-70 antibodies are specific for which condition?

A

Diffuse systemic sclerosis

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2
Q

Which autoantibodies can be seen in anti-phospholipid syndrome?

A

Anti-cardiolipin antibodies and lupus anticoagulant

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3
Q

Anti-Ro antibodies can be seen in which conditions?

A

SLE, Sjogren’s

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4
Q

ANA is a very sensitive antibody but it is not very specific. Name some conditions it can be seen in?

A

SLE, Sjogren’s, systemic sclerosis, mixed connective tissue disease

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5
Q

Which autoantibodies are specific for Sjogren’s syndrome?

A

Anti-La

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6
Q

pANCA antibodies are seen in which condition? Which other antibodies may be seen in this condition?

A

EGPA (and MPA), also associated with anti-MPO

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7
Q

Anti-dsDNA antibodies are specific for which condition?

A

SLE

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8
Q

Anti-centromere antibodies are specific for which condition?

A

Limited systemic sclerosis

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9
Q

cANCA antibodies are seen in which condition? Which other antibodies may be seen in this condition?

A

GPA, also associated with anti-PR3

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10
Q

Anti-CCP antibodies are specific for which condition?

A

Rheumatoid arthritis

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11
Q

Anti-Sm antibodies are mostly related to autoimmune hepatitis. It can however be associated with which rheumatological condition?

A

SLE

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12
Q

Anti-Jo-1 antibodies are specific for which condition?

A

Myositis (i.e. polymyositis/dermatomyositis)

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