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Pharmacology > Autocoid Drugs > Flashcards

Autocoid Drugs Flashcards

(68 cards)

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1
Q

MOA of omalizumab

A

Binds to IgE receptors on mast cells and basophils

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2
Q

MOA of diphenhydramine

A

Blocks the H-1 histamine receptor

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3
Q

MOA of cimetidine

A

Blocks the H-2 histamine receptors

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4
Q

MOA of the -lukasts

A

blocks the leukotriene receptor

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5
Q

MOA of cromolyn

A

inhibits mas cell degranulation

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6
Q

MOA of theophylline and roflumilast

A

inhibits phosphodiesterases

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7
Q

1st generation antihistamines

A

diphenhydramine
meclizine - less sedation
cyclizine - less sedation

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8
Q

2nd generation antihistamines

A

Certizine
Desloratadine
Fexofenadine
Terfenadine

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9
Q

1st generation antihistamines differ from 2nd generation

A

All 1st generation have anticholinergic effects whereas 2nd generation do not

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10
Q

Busprione

A

5-HT1A partial agonist
used an as anxiolytic (GAD)

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11
Q

5-HT agonists with serious adverse effect of Pulmonary HTN and valvular lesions

A

Fenfluramine
Dexfenfluramine
Phentermine

(Fen-Phen)

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12
Q

Cisapride

A

5-HT4 agonist

use: GERD/GI motility

enhances the release of ACh

cardia arrhythmias

prolongs QT

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13
Q

Tegaserod

A

partial 5-HT4 agonist used for IBS-C

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14
Q

-triptans

A

5-HT1D agonist

treatment for migraine headaches

Sumatriptan, naratriptan, rizatriptan, eletriptan, frova triptan, and zolmitriptan

can cause coronary vasospasm and angina

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15
Q

Lorcaserin

A

5-HT 2c agonist for treatment for of obesity

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16
Q

Lasmiditan

A

5-HT 1F receptor agonist for migraine headaches (new)

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17
Q

Ondansetron, ganisteron, dolasteron

A

The -setrons

5-HT3 antagonist used for treatment of nausea and vomiting during cancer chemotherapy

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18
Q

Aloserton

A

treats IBS-D

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19
Q

Morning sickness preferred treatment drugs

A

doxylamine/pyridoxine

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20
Q

ergot alkaloids

A

Erogtamine
Dihydroergotamine

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21
Q

Ergonovine/methylergonovine

A

treats post partum hemorrhage

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22
Q

Lysergic acid diethylamide

A

hallucinogen

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23
Q

Topiramate

A

anticonvulsant that prevents migraine

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24
Q

Valproic acid

A

anticonvulsant that prevents migraine

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25
prolong and excessive treatment with dihydroergotamine
results in gangrene
26
Dry hacking cough
ACE inhibitors Lisinopril
27
MOA of ACE Inhibitors
reduces angiotensin II formation and lowers BP & cardiovascular disease through 4 mechanisms 1. reduced AT vasoconstrictions = vasodilation lowers BP by reducing PVR w/o reflex tachycardia 2. reduce AT II will decrease aldosterone release from adrenal medulla, decrease fluid volume and decrease CO 3. reduced destruction of bradykinin = increase bradykinin levels - vasodilation to enhance BP lowering 4. decrease vascular and cardia hypertrophy & remodeling
28
Ramipril
does not negatively effect blood lipids or glucose does not cause reflex tachycardia
29
JNC 8 Recommendations
General non-black population: thiazides, CCB, ACEI, or ARB General black population: thiazides or CCB initially CKD: treatment should include ACEI or ARB Do not use ACEI and ARB together for risk of hyperkalemia.
30
Angina pectoris
use: beta blocker diltiazem verapamil don't use: hydralazine minoxidil
31
Asthma & COPD
use: CCB ACEI don't use: beta blocker
32
BPH
use: alpha blocker don't use: none listed
33
Collagen disease (SLE)
use: ACEI (but not captopril) don't use hydralazine methyldopa
34
Depression
use: ACEI or ARB CCB don't use: centrally acting alpha 2 agonists beta blocker reserpine
35
DM
use: ACEI or ARB CCB Angiotensin receptor antagonist don't use: beta blocker diuretic
36
Gout
don't use diuretic
37
Heart failure
use: ACEI inhibit or ARB diuretic hydralazine beta blocker don't use: CCB
38
endoge3nous substances that is thought to produce dry hacking cough in a patient taking enalapril
bradykinin
39
AT II properties
increase IP3, DAG via AT1 G-protein receptors. constricts arterioles, increase aldosterone secretion
40
Bradykinin properties
Increase IP3, DAG, NO, cGMP. Dilates arterioles, increases capillary permeability, stimulates sensory nerve endings
41
Calcitonin gene-related peptide (CGRP)
an extremely potent vasodilator; causes hypotension and reflex tachycardia
42
Endothelin properties
increase IP3, DAG via G-protein-coupled ETa and ETb receptors. Synthesized in vascular endothelium. constrict most vessels, may play a pathophysiologic role in pulmonary hypertension
43
Activation of which of the following receptors in an experimental subject would be responsible for the RELEASE of adrenocorticotropic hormone (ACTH) from pituitary corticotropes?
V1b
44
Vasopressin receptors
V1a - vascular smooth muscle causing vasoconstriction = Gq pathway V1b - potentiate release of ACTH by pituitary corticotropes = Gq pathway V2 - in renal cells produce antidiuresis by increasing water permeability and reabsorption in collecting tubules (insertion of water channels) = Gs pathway
45
Which of the following prostaglandins is likely to cause bronchoconstriction in a asthmatic man?
TXA2; PGF2alpha, & PGD2
46
prostaglandin preparations appropriate used as an ophthalmic solution to LOWER intraocular pressure (IOP) in open-angle glaucoma?
Latanoprost (PGF2alpha)
47
Eicosanoids
Alprostadil Carboprost tromethamine Dinoprostone Epoprostenol Latanoprost Misoprostol
48
Inhibitor of eicosanoid synthesis
corticosteroids NSAIDs
49
Leukotriene receptor antagonist
Zafirlukast Montelukast
50
Ergot Alkaloids and related compounds
Bromocriptine Dihydroergotamine Ergonovine Ergotamine Lysergic Acid diethylamide (LSD)
51
AT II converting enzyme inhibitors
captopril enalapril
52
Serotonin agonists
Sumpatriptan (5-HT1d) Ciapride, Tegaserod, (5-HT4) Buspirone (5-HT1A)
53
Peptides
Bradykinin Vasopressin DDAVP Angiotensin II
54
Oxytocic actions
PGE1 PGE2 PGF2a
55
Dinoprostone
used for cervical ripening PGE2 Misoprostol - abortion
56
Oxytocin
posterior pituitary hormones use clinically to control postpartum bleeding after delivery of the placenta Induce milk ejection
57
Molecular target: terbutaline
Beta-2 recptors
58
Molecular target: steriods
nuclear receptor driven gene expression
59
Molecular target: -lukasts
leukotriene receptors
60
molecular target: zileuton
leukotriene synthesis
61
molecular target: ipratropium
muscarinic receptor
62
molecular target: theophylline
phosphodiesterase
63
Monoclonal antibodies for asthma
Omalizumab Mepolizumab Reslizumab Benraliumab
64
Glucocorticoids
alter nuclear receptor driven gene expression beclomethasone budesonide flunisolide fluticasone mometasone ciclesonide (prodrug)
65
Drug critical to keep the plasma concentration within a narrow range
Theophylline
66
Emergency treatment for severe asthmas or COPD when bronchodilators do not resolved the airway obstruction
Oral steroids - prednisone Parenteral - methylprednisolone
67
long acting beta 2 agonist risk
asthma-related deaths r/t down regulation of receptors
68
Omalizumab
antibodies directed towards the IgE high affinity Fc receptor on mast cells control moderate to severe asthma not controlled by inhaled steriods

Pharmacology (5 decks)

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