Autoimmune disease

Question 1

Hypersensitivity immune response Type 1

Answer 1

Allergy and Atopy = Asthma or allergies
- IgE mediated

Question 2

Hypersensitivity immune response Type 2

Answer 2

Antibody-mediated hypersensitivity = Graves
- IgE mediated cytotoxic

Question 3

Hypersensitivity immune response Type 3

Answer 3

Immune complex-mediated hypersensitivity = Lupus
- immune complex mediated

Question 4

Hypersensitivity immune response Type 4

Answer 4

Delayed type hypersensitivity = MS
- cell mediated

Question 5

Transplantation immunological reactions

Answer 5

• Hyperacute rejection
• Acute rejection
• Chronic rejection

Question 6

Minutes after transplant

Answer 6

Hyperacute reaction

Question 7

Highest risk window one week to three months after transplant

Answer 7

Acute rejection

Question 8

Months to year after transplantation

Answer 8

Chronic rejection

Question 9

How do vaccines work?

Answer 9

Stimulates a response from the immune system to a virus or bacteria.
This creates a “memory” in the immune system.

Question 10

Immune response in tumors

Answer 10

• It can inhibit tumor growth
• It can promote tumor growth
• Immunodeficiency can predispose to virally induced cancer
• Some tumors generate immunosuppressive microenvironment

Question 11

Cancer immunity cycle

Answer 11

1. Release of cancer cell antigens
2. Cancer antigen presentation
3. Priming and activation
4. Trafficking of T cells to tumors
5. Infiltration of T cells into tumors
6. Recognition of cancer cells by T cells
7. Killing of cancer cells

Question 12

Terapia de células T con CAR

Answer 12

1. Se extrae sangre del paciente para obtener células T
2. Se preparan las células T con CAR en el laboratorio
3. Se reproducen millones de células T con CAR
4. Las células T con CAR se unen a las células cancerosas y las destruyen