Autoimmune disease Flashcards
(16 cards)
What are the key diseases in autoimmunity
IPEX syndrome
Autoimmune blisteringdisease
SLE
Molecular mimicry
What is central tolerance
in the thymus where t cells are educated to distinguish self from non self antigens
What is peripheral toleramce
it is in various organs and prevents immune response against self tissues outside of the thymus
What is pemphigus vulagris
it is a autoimmune blistering disease affecting the skin and mucosa membranes, causing the loss of cell adhesion
how is pemph vulgaris diagnosed
using direct immunofluorescence which shows igg and complements in the affected skin
What is the treatment for pemph vulgaris
steriods, immunosuppresants and rituximab
What is pemph foliaceus
its a endemic form of autoimmune disease found in brazil it is caused by antibodies against Dsg1
What is systemic lupus
disease affecting multiple organs
What antibodies are involved in sle
ANA ,dsDNA and ENA
what are some trigger factors for SLE
uv light , infections, stress
WHat is the pathogenesis of sle
Poor clearance of apoptotic cells expose self antigens , leading to immune activation. Molecular mimicry can occur
Treatement options for SLE
UV protection , medications , chloroquine , methotrextate and other immuno suppressants
What is molecular mimicry in autoimmunity
Molecular mimicry is when pathogens have antigens that resemble self antigens triggering an immune response against its bodies own tissues
How does failure in apoptopic clearance contribute to autoimmunity
it exposes self antigens , leading to an immune response against its bodies own tissues
What role do tregs play in maintaing tolerance
they supress autoreactive immune responses
