Autoimmune liver disease

Question 1

What will be seen on histology following biopsy of a liver undergoing AIH?

Answer 1

Lymphoplasmacytic infiltrate

Question 2

Which immunoglobulin is raised in nearly all active cases of AIH?

Answer 2

IgG

Question 3

Which antibody is present in paediatric AIH?

Answer 3

Anti-LKM1

Question 4

Which antibody is elevated in primary biliary cholangitis?

Answer 4

AMA

Question 5

Which liver enzyme is chronically elevated in PBC?

Answer 5

ALP

Question 6

What is affected in PBC?

Answer 6

Interlobular bile ducts damaged by chronic autoimmune granulomatosis

Question 7

How is PBC treated?

Answer 7

Ursodeoxycholic acid with colestyramine for pruritis

Question 8

What does PSC affect?

Answer 8

Intra and extra hepatic bile ducts

Question 9

What does liver biopsy of PSC show?

Answer 9

Obliterative fibrous cholangitis

Question 10

What is the difference between transudate and exudate ascites?

Answer 10

Transudate ascites is high in protein and is typically a result of heart failure or Budd Chiari syndrome.
Exudate ascites is low in protein and is commonly seen in cirrhosis and nephrotic syndrome

Question 11

What does TIPSSS stand for?

Answer 11

Transjugular intrahepatic portosystemic shunt stent