Autoinflammation

Question 1

A lack of mucin layer leads to a lack of Akkermansia, why?

Answer 1

Because Akkermansia live of eating the mucin layer. If there is no mucin layer they have nothing to feed on.

Question 2

Having a weak mucin layer can lead to what?

Answer 2

Leaky gut, translocation of bacteria

Question 3

What can have a positive effect on autoimmunity?

Answer 3

Fruits and vegetables
Omega 3
Vitamin D
Minerals

Question 4

What can have a negative effect on autoimmunity?

Answer 4

Junk food
Malnourishment
Specific deficits

Question 5

Can the conditions the animals lived under have an effect on us when we eat the meat?

Answer 5

Yes. Can be pro-inflammatory if the animals were bred under bad conditions

Question 6

What percentage of diseases are due to diet?

Answer 6

20 %

Question 7

Can emulsifying agents dissolve the mucin layer?

Answer 7

Yes

Question 8

Is the food we eat more or less varied today than ancestors?

Answer 8

Less.
“Below a superficial surface of different spices (sushi, thai,
pizza etc) our food becomes more and more homogenous and
is distributed from fewer producers”

““People think they eat a more global and varied diet
than their ancestors but from a microbial perspective
these products become more and more deprived.”

Question 9

In what 3 ways do microorganisms give health benefits?

Answer 9

Stabilize the intestinal barrier
➢stimulating epithelial growth
➢mucus secretion
➢motility
Enhance innate immunity
➢inhibition of IL-10
➢stimulation of secretory IgA and neutrophils
➢reduction of inflammatory cytokines
Suppresses pathogenic microorganisms
➢e.g., E. coli and Enterobacteriaceae