Autonomic Drugs Flashcards Preview

SECOND YEAR > Autonomic Drugs > Flashcards

Flashcards in Autonomic Drugs Deck (47):
1

Drugs that act on receptors activated by Ach (muscarinic and nicotinic)

Cholinergic drugs

2

Drugs that act on receptors activated by NE or E

Adrenergic drugs

3

Cholinergic agonists that look and act like Ach

Direct Acting

4

Cholinergic agonists that increase the amount of Ach

Indirect Acting

5

Drug used for diagnosis of myasthenia gravis

Edrophonium

6

Drug of choice for myasthenia gravis

Neostigmine

7

Drug for maintenance of myasthenia gravis

Pyridostigmine

8

Site of action of ganglionic blockers (cholinergic antagonist)

Nicotinic receptor

9

Site of action of antimuscarinic drugs (cholinergic antagonist)

Muscarinic receptor

10

Site of action of neuromuscular blockers (cholinergic antagonist)

Nicotic receptor on striated muscle

11

Atropine is a ganglionic blocker. True or false?

False.
It's an antimuscarinic drug.

12

The three antimuscarinic drugs used to TREAT the manifestations of Parkinson's disease

Benztropine
Trihexyphenidyl
Biperiden

13

Why are ganglion-blocking drugs not commonly given?

They also stimulate the sympathetic so they have so many side effects.

14

Representative of ganglion-blocking drugs

Trimetaphan

15

Antimuscarinic drug that is important in producing complete skeletal muscle relaxation in surgery

Neuromuscular blockers

16

Prototype of non-depolarizing NM blockers

Tubocurarine - competitive blocking at NMJ leading to flaccid paralysis

17

Why is succinylcholine used as a muscle relaxant when it's a nicotinic agonist?

Succinylcholine is an Ach mimic. It will stimulate muscle contraction. The muscle contraction will be sustained, leading to muscle weakness.

18

Antimuscarinic drugs that increase cholinesterase

Cholinesterase regenerators

19

Mechanism of organophosphate poisoning

Organophosphates block ChE leading to Ach excess.

20

Antidote of choice for organophosphate poisoning

Pralidoxime

21

Mechanism of cholinesterase regenerator against organophosphate poisoning

The oxime group in ChE bind to the phosphorous part of organophosphate.
(Suicide inhibitor)

22

Smooth muscle contraction?

Alpha1
Alpha2
Beta1
Beta 2

Alpha 1 - keyword: CONTRACTION

23

Increased force of contraction of heart?

Alpha1
Alpha2
Beta1
Beta 2

Alpha 1 - keyword: CONTRACTION

24

Platelet aggregation

Alpha1
Alpha2
Beta1
Beta 2

Alpha2

25

Inhibits transmitter release?

Alpha1
Alpha2
Beta1
Beta 2

Alpha2

26

Inhibits lipolysis?

Alpha1
Alpha2
Beta1
Beta 2

Alpha2

27

Heart, juxtglomerular apparatus

Alpha1
Alpha2
Beta1
Beta 2

Beta1

28

Respiratory, uterine, vascular smooth muscle

Alpha1
Alpha2
Beta1
Beta 2

Beta2

29

Promotes potassium uptake?

Alpha1
Alpha2
Beta1
Beta 2

Beta2

30

Relaxes detrusor muscle

Beta1
Beta2
Beta3
D1
D2

Beta3

31

Activates lipolysis

Beta1
Beta2
Beta3
D1
D2

Beta3

32

Modulates transmitter release

Beta1
Beta2
Beta3
D1
D2

D2

33

Functions for negative feedback

Alpha1
Alpha2
Beta1
Beta2

Alpha2

34

Indirect acting adrenergic agonist that is a precursor for tyrosine

Tyramine

35

Beta blockers that have alpha-blocking properties

Carvedilol and Labetalol

36

Beta blocker that has the longest half-life

Nadolol

37

Beta blocker that has the shortest half life

Esmolol

38

Beta blocker that has the highest BA

Penbutolol

39

Beta blockers with some beta agonistic properties

Acetabulol and Pindolol

40

Most common use of beta blockers

Hypertension and chest pain

41

Action of acetylcholine

Muscarinic
Nicotinic
Both

Both

42

Action of bethanecol

Muscarinic
Nicotinic
Both

Muscarinic

43

Action of carbachol

Muscarinic
Nicotinic
Both

Both

44

Action of pilocarpine

Muscarinic
Nicotinic
Both

Muscarinic

45

Action of nicotine

Muscarinic
Nicotinic
Both

Nicotinic

46

Why give adreneceptor agonist to an ADHD patient?

ADHD patients only have attention deficit. They are not hypermetabolic. A stimulant will increase attention span.

47

Why do the effects of amphetamine last for long?

They are resistant to MAO and COMT