Autonomic Drugs

Question 1

Drugs that act on receptors activated by Ach (muscarinic and nicotinic)

Answer 1

Cholinergic drugs

Question 2

Drugs that act on receptors activated by NE or E

Answer 2

Adrenergic drugs

Question 3

Cholinergic agonists that look and act like Ach

Answer 3

Direct Acting

Question 4

Cholinergic agonists that increase the amount of Ach

Answer 4

Indirect Acting

Question 5

Drug used for diagnosis of myasthenia gravis

Answer 5

Edrophonium

Question 6

Drug of choice for myasthenia gravis

Answer 6

Neostigmine

Question 7

Drug for maintenance of myasthenia gravis

Answer 7

Pyridostigmine

Question 8

Site of action of ganglionic blockers (cholinergic antagonist)

Answer 8

Nicotinic receptor

Question 9

Site of action of antimuscarinic drugs (cholinergic antagonist)

Answer 9

Muscarinic receptor

Question 10

Site of action of neuromuscular blockers (cholinergic antagonist)

Answer 10

Nicotic receptor on striated muscle

Question 11

Atropine is a ganglionic blocker. True or false?

Answer 11

False.

It’s an antimuscarinic drug.

Question 12

The three antimuscarinic drugs used to TREAT the manifestations of Parkinson’s disease

Answer 12

Benztropine
Trihexyphenidyl
Biperiden

Question 13

Why are ganglion-blocking drugs not commonly given?

Answer 13

They also stimulate the sympathetic so they have so many side effects.

Question 14

Representative of ganglion-blocking drugs

Answer 14

Trimetaphan

Question 15

Antimuscarinic drug that is important in producing complete skeletal muscle relaxation in surgery

Answer 15

Neuromuscular blockers

Question 16

Prototype of non-depolarizing NM blockers

Answer 16

Tubocurarine - competitive blocking at NMJ leading to flaccid paralysis

Question 17

Why is succinylcholine used as a muscle relaxant when it’s a nicotinic agonist?

Answer 17

Succinylcholine is an Ach mimic. It will stimulate muscle contraction. The muscle contraction will be sustained, leading to muscle weakness.

Question 18

Antimuscarinic drugs that increase cholinesterase

Answer 18

Cholinesterase regenerators

Question 19

Mechanism of organophosphate poisoning

Answer 19

Organophosphates block ChE leading to Ach excess.

Question 20

Antidote of choice for organophosphate poisoning

Answer 20

Pralidoxime

Question 21

Mechanism of cholinesterase regenerator against organophosphate poisoning

Answer 21

The oxime group in ChE bind to the phosphorous part of organophosphate.
(Suicide inhibitor)

Question 22

Smooth muscle contraction?

Alpha1
Alpha2
Beta1
Beta 2

Answer 22

Alpha 1 - keyword: CONTRACTION

Question 23

Increased force of contraction of heart?

Alpha1
Alpha2
Beta1
Beta 2

Answer 23

Alpha 1 - keyword: CONTRACTION

Question 24

Platelet aggregation

Alpha1
Alpha2
Beta1
Beta 2

Answer 24

Alpha2

Question 25

Inhibits transmitter release? Alpha1 Alpha2 Beta1 Beta 2

Answer 25

Alpha2

Question 26

Inhibits lipolysis? Alpha1 Alpha2 Beta1 Beta 2

Answer 26

Alpha2

Question 27

Heart, juxtglomerular apparatus Alpha1 Alpha2 Beta1 Beta 2

Answer 27

Beta1

Question 28

Respiratory, uterine, vascular smooth muscle Alpha1 Alpha2 Beta1 Beta 2

Answer 28

Beta2

Question 29

Promotes potassium uptake? Alpha1 Alpha2 Beta1 Beta 2

Answer 29

Beta2

Question 30

Relaxes detrusor muscle ``` Beta1 Beta2 Beta3 D1 D2 ```

Answer 30

Beta3

Question 31

Activates lipolysis ``` Beta1 Beta2 Beta3 D1 D2 ```

Answer 31

Beta3

Question 32

Modulates transmitter release ``` Beta1 Beta2 Beta3 D1 D2 ```

Answer 32

D2

Question 33

Functions for negative feedback Alpha1 Alpha2 Beta1 Beta2

Answer 33

Alpha2

Question 34

Indirect acting adrenergic agonist that is a precursor for tyrosine

Answer 34

Tyramine

Question 35

Beta blockers that have alpha-blocking properties

Answer 35

Carvedilol and Labetalol

Question 36

Beta blocker that has the longest half-life

Answer 36

Nadolol

Question 37

Beta blocker that has the shortest half life

Answer 37

Esmolol

Question 38

Beta blocker that has the highest BA

Answer 38

Penbutolol

Question 39

Beta blockers with some beta agonistic properties

Answer 39

Acetabulol and Pindolol

Question 40

Most common use of beta blockers

Answer 40

Hypertension and chest pain

Question 41

Action of acetylcholine Muscarinic Nicotinic Both

Answer 41

Both

Question 42

Action of bethanecol Muscarinic Nicotinic Both

Answer 42

Muscarinic

Question 43

Action of carbachol Muscarinic Nicotinic Both

Answer 43

Both

Question 44

Action of pilocarpine Muscarinic Nicotinic Both

Answer 44

Muscarinic

Question 45

Action of nicotine Muscarinic Nicotinic Both

Answer 45

Nicotinic

Question 46

Why give adreneceptor agonist to an ADHD patient?

Answer 46

ADHD patients only have attention deficit. They are not hypermetabolic. A stimulant will increase attention span.

Question 47

Why do the effects of amphetamine last for long?

Answer 47

They are resistant to MAO and COMT