Autonomic pharm

Question 1

Preganglionic fibers from cranial and sacral areas
Long PREganglionic fiber releases ACh
Short POSTganglionic fiber, close to organ, releases ACh

Answer 1

Parasympathetic

Question 2

Preganglionic fibers from thoracic and lumbar
Paravertebral chains
Allows coordination
Short PREganglionic fibers release ACh
Long POSTganglionic fibers release NE
Some release DA, Epi, ACh

Answer 2

Sympathetic

Question 3

Neurotransmitter for ALL pregang fibers
Postgang para fibers
Symp innervation to sweat glands
Innervates adrenal medulla
Motor neurons to skeletal muscle

Answer 3

Acetylcholine

Question 4

Neurotransmitter for Postgang symp fibers
EXCEPT sweat glands
Released by adrenal medulla

Answer 4

Norepinephrine

Question 5

Neurotransmitter for renal vasculature

Answer 5

Dopamine

Question 6

Cholinergic transmission

Answer 6

ACh synthesized, stored, released to stimulate receptors, inactivated by acetylcholinesterase

Question 7

Adrenergic transmission

Answer 7

Tyrosine enters nerve terminal, converted to DOPA the dopamine, then dopamine to NE then NE acts on receptors

Question 8

Metryosine

Answer 8

blocks DOPA synthesis

Question 9

Reserpine

Answer 9

depletes NE in vesicle

Question 10

Cocaine

Answer 10

TCAs block reuptake

Question 11

Metabolized by MAO and COMT

Answer 11

NE

Question 12

Cholinergic Receptors: M1

Answer 12

Sweat glands, CNS

-Gq/11, PLC, IP3, DAG

Question 13

Cholinergic Receptors: M2

Answer 13

Decrease heart rate and conduction

Heart, smooth muscle, presynaptic
-inhibits adenylyl cyclase, Gi

Question 14

Cholinergic Receptors: M3

Answer 14

Cause bronchoconstriction

Exocrine, smooth muscle, endothelium
-Gq/11, PLC, IP3, DAG

Question 15

Cholinergic Receptors: Nicotinic

Answer 15

Na+ channel, Nn, Nm

Question 16

Adrenergic Receptors: Alpha 1

Answer 16

Constrict most blood vessels

Smooth muscle, excitatory
-Gq/11, PLC, IP3, DAG

Question 17

Adrenergic Receptors: Alpha 2

Answer 17

Presynaptic nerve terminals, some smooth muscle

-Gi; inhibits adenylyl cyclase

Question 18

All beta receptors

Answer 18

stimulate adenylyl cyclase, Gs

Question 19

Beta 1

Answer 19

heart, increase rate and force, increase AV conduction and contractility

Question 20

Beta 2

Answer 20

Relax bronchioles, heart, smooth muscle in blood vessel

Question 21

Beta 3

Answer 21

lipolysis in fat cells

Question 22

Dopamine receptors: D1, D5

Answer 22

Brain and vascular bed

Usually increase cAMP

Question 23

Dopamine receptors: D2, D3, D4

Answer 23

Brain and other tissues

Decrease cAMP

Question 24

Pupil dilation

Answer 24

Sympathetic stimulation of the radial muscle

Alpha 1 receptor

Question 25

Constriction of the pupil

Answer 25

Parasympathetic stimulation tightens circular muscle | M3 receptor

Question 26

Iris circular muscle

Answer 26

Contraction causes miosis (pupil constriction)

Question 27

Ciliary Muscle

Answer 27

Contraction shifts lens and causes accommodation for near vision Increases outflow of aqueous humor into canal of Schlemm

Question 28

Alpha receptors in eye: | Adrenergic effects

Answer 28

Contract radial muscle Mydriasis w/o cyclopegia Decrease intraocular pressure

Question 29

Alpha blockade | Adrenergic effects

Answer 29

prevents mydriasis

Question 30

Beta receptors of eye | Adrenergic effects

Answer 30

Increase production of aqueous humor Increase intraocular pressure -Beta blockers used to tx glaucoma decrease secretion