Endo Drugs

Question 1

regulate Ang II & K

Increase Na,↑H2O, ↓K retention

Answer 1

Mineralocorticoids

Question 2

1. Stimulate ACTH
2. Stress hormones
3. ↑circulating glucose, FFA’s, AA’s

Answer 2

Glucocorticoids

Question 3

Inhibits steroid synthesis (high dose) Preoperative suppression in Cushing’s

Answer 3

Ketoconazole (Nizoral)

NON-SELECTIVE!

Question 4

Inoperable Cushing’s patients

Answer 4

Mifepristone (RU486)

Question 5

Suppresses release of LH/FSH

Answer 5

GnRH:
Leuprolide (Lupron)
Goserelin(Zoladex)
Cetrorelix (Cetrotide)
Ganirelix (Antagon)

Question 6

Women: stimulates ovarian follicle development
Men: stimulates spermatogenesis

Answer 6

Urofollitropin (Bravelle)

Question 7

Simulates ovulation, lutenization, steroid production (estrogen & progesterone)

Answer 7

hCG (Pregnyl)

Question 8

First line fertility drug

Answer 8

Clomiphene (Clomid)

Question 9

DOC: induction of labor at termHemorrhage (PPH) prevention, milk let down

Answer 9

Oxytocin (Pitocin)

Question 10

Prophylactic in wks 16-37 - NOT FOR ACUTE TX - use in high risk women w/ Hx of preterm birth

Answer 10

Progesterone

Question 11

EMERGENCY USE ONLY - uterine rupture - causes cervicouterine relaxation

Answer 11

Nitroglycerin

Question 12

Direct relaxation of myometrium - inhibit preterm labor

Answer 12

Ethanol

Question 13

Causes timed contractions similar to natural labor

Answer 13

Oxytocin (Pitocin)

Question 14

BLACK BOX for diarrhea

Answer 14

Dinoprostone (Prostin E2)

Question 15

Promotes insertion of GLUT4s into membrane

Answer 15

Insulin preparations

Question 16

Stimulate insulin release from pancreatic beta-cells

Indirectly potentiate action at target cells

Answer 16

Anti-diabetics: Sulfonylureas

Question 17

Bind K receptors on beta cells = ↑insulin release

NOT A SULFA DRUG

Answer 17

Anti-diabetics: Meglitinides

Question 18

USE IN TREATING METABOLIC SYNDROME

DOES NOT WORK ON BETA CELLS

Answer 18

Biguanides: Metformin (Glucophage)

Question 19

DO NOT ↑INSULIN RELEASE

Answer 19

Thiazo’s:
Pioglitazone (Actos)
Rosiglitazone (Avandia)

Question 20

DOC: Hypothyroidism

Maintenance

Answer 20

Levothyroxine sodium (Synthroid)