Autonomic Pharmacology Flashcards Preview

Pharmacology > Autonomic Pharmacology > Flashcards

Flashcards in Autonomic Pharmacology Deck (54):
1

Primary transmitter in all autonomic ganglia and at the synapses bet parasympathetic postganglionic neurons and their effector cells

Acetylcholine

2

What is the enzyme used in the synthesis of Ach from acetyl coa and choline?

Choline acetyltransferase (ChAT)

3

Choline transport is inhibited by?

Hemicholinium

4

ACh transport into vesicle for storage is mediated by?

Vesamicol

5

At what step in Ach pathway does Botulinum toxins affect?

Step 3: Release (alter synaptobrevin to prevent release of ACh)

6

Degradation of ACh into choline and acetate is mediated by?

Acetylcholinesterase

7

What indirect acting cholinomimetics inhibits step 4 of ACh pathway?

Neostigmine, Carbamates, Organophosphates

8

Betanechol is under what class of drug?

Cholinomimetic (direct, muscarinic)

9

Bladder and bowel atony ( post surgical/spinal)

Betanechol

10

Cevilemine is under what drug class?

Pilocarpine

11

What is the MOA of Pilocarpine?

Muscarinic M3 receptors in ciliary muscle and salivary glands

12

What is the triad of Sjogren Syndrome?

xerostomia, xeropthalmia, rheumatoid arthritis

13

What is the MOA of Nicotine?

Activate Ach receptors (Nn/ Nm)

14

What is the MOA of Edrophonium?

Inhibition of acetylcholinesterase; amplify endogenously released acetylcholine

15

What is the test used to diagnose Myasthenia gravis?

Tensilon test

16

What is the primary use of edrophonium?

Myasthenia gravis

17

The reversal of neuromuscular blockade is done with the use of what drug?

Neostigmine

18

Muscarinic effects of neostigmine are blocked by?

Atropine

19

Donepezil, Galantamine, and Tacrine are related to what drug?

Rivastigmine

20

Rivastigmine is used for what disease?

Alzheimers Disease

21

Organophosphate poisoning S/Sx:

DUMBBELSS: Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation, Lacrimation, Sweating, Salivation

22

What are the two drugs used for organophosphate poisoning?

Atropine and Pralidoxime

23

What antidote for organophosphate poisoning is a cholinesterase regenerator?

Pralidoxime

24

Why is Pralidoxime given 6-8 hours after exposure to pesticides?

Aging of organophosphate bond with cholinesterase

25

What is the MOA of Atropine?

Competitively blocks all muscarinic receptors

26

What cholinergic drug is used for Parkinson's disease?

Benztropine

27

What are three muscarinic antagonists used for Parkinson's disease?

Trihexyphenidyl, Benztropine, Biperiden

28

What is the MOA of Ipratropium?

block muscarinic receptor in bronchial smooth muscle, prevent vagal stimulated bronchoconstriction

29

Why is ipratropium used in COPD patients?

less to cause tachycardia and cardiac arrythmia

30

What cholinergic antagonist drug is used for motion sickness?

Scopolamine

31

What is the MOA of dicyclomine?

competitively blocks M3 receptor (selective)

32

Atropine Toxicity?

Mad Hatter: hyperthermia, decreased sensation, cutaneous vasodilation, loss of accomodation, psychosis

33

What cholinergic antagonist causes postural hypotension?

Hexamethonium

34

Examples of nondepolarizing neuromuscular blockers?

Tubocuraraine, Pancuronium, Atracurium, Vecuronium

35

Example of depolarizing neuromuscular blockers?

Succinylcholine

36

Norepinephrine is the primary transmitter at sympathetic postganglionic neuron effector cell synapses except for?

(1) eccrine sweat glands; (2) vasodilator sympathetic fibers in skeletal muscle

37

Norepinephrine pathway: what inhibits tyrosine hydroxylation in step 1?

Metyrosine

38

What inhibits norepinephrine and dopamine transport into vesicles?

Monoamine oxidase (cytoplasm)

39

What inhibits vesicular transport in Step 2 of NE pathway?

Reserpine

40

What inhibits NE release in Step 3?

Guanethedine

41

What promotes release of NE in Step 3?

Amphetamines and Tyramine

42

What inhibits diffusion and reuptake via NET and DAT in synaptic clefts?

Cocaine and TCA

43

Examples of COMT inhibitors?

tolcapone and entecapone

44

What sympathomimetics the last line for cardiogenic shock?

Norepinephrine

45

Common side effect of phenylephrine?

Rebound nasal congestion

46

What is given for rebound hypertension?

Phentolamine

47

What nonselective alpha blockers are used for pheochromocytoma?

Phenoxybenzamine, Phentolamine, Tolazoline

48

What 2 drugs (adrenergic, nonselective alpha blockers) used as antidote to alpha 1 agonist overdose?

Phentolamine and Tolazoline

49

What adrenergic antagonist is selective for prostatic smooth muscles?

Tamsulosin

50

Common side effect of phentolamine and tolazoline?

reflex tachycardia

51

Nonselective beta blockers used for glaucoma?

Timolol and Betaxolol

52

What 2 drugs, similar to propanolol, has alpha and beta effects?

Labetalol and Carvedilol

53

Two examples of beta blockers with ISA?

Pindolol and Acebutol

54

What selective beta 1 blocker used for supraventricular tachycardia?

Esmolol