Autonomics Flashcards Preview

Physiology Exam V > Autonomics > Flashcards

Flashcards in Autonomics Deck (21):
1

ANS is a part of what

peripheral nervous system

2

sympathetic nervous system location

T1-L3
nervous line in lateral horn of spinal cord

3

What is Ach

preganglion NT

4

what is NE

postganglionic NT

5

parasympathetic nerves

CN III, VII, IX, X
Sacral S2-4

6

path of long pre-ganglionic nercous

pelvic ganglia to short post-ganglionic fibers to target

7

path of shorter preganglionic neous

paravertebral, prevertebral or specialized ganglia to longer post ganglionic nerous to target

8

How is Ach syntheized

choline transporter takes choline into cell, then conjugated to acteyl coA via choline acetyltransferase

9

Hemicholiniums

blocks choline transporter taking choline into cell

10

how is Epi synthesized

tyrosine to DOPA to doapmine to NE to Epi

11

metyrosin

blocks conversion of tyrosin to DOPA

12

how is ach stored

VAT brings Ach into vesicle

13

vesamicole

blocks VAT bringing Ach into vesicle

14

how is Epi stored

VMAT transports into vesicles where synthesis increases

15

reserpine

blocks WMAT transport into vesicles

16

how is ach released

depolarization caused by ca++ influx with calmodulin activates VAMPS and SNAPs

17

botulinum

blocks release of Ach

18

How is Epi released

similiar to Ach

19

bretylium

blocks release of epi

20

how is Ach terminated

acetylcholinesterase hydrolyzes Ach in synaptic cleft

21

How is epi terminated

diffusion at synapse into circulation
reuptake via NET1 or NET2, then metabolized by MAO following reuptake