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Physiology Exam V > Pancreas > Flashcards

Flashcards in Pancreas Deck (41):
1

What are 3 key cell types that are improtant to exocrine fucntion of pancreas

acinar, duct, goblet

2

function of acinar cell

protein synthesizing cells
secrete digestive enzyme and fluid

3

functino of duct cell

secretes bicarb
helps with ion and water transport

4

function of goblet cell

secrete mucin

5

What are 2 primary stimuli for fluid and enzyme secretion by pancreatic acinar cells

CCK
Ach

6

function of CCK

promote fluid and enzyme secretion
promote through Ca++ signaling docking and vesicular release
will give neg feedback after there is enough fluid/enzymes

7

what do CCK and Ach both do

promote vesicle fusion, regulate Cl- ion channel

8

how are zymogens stores in pancrea

in vesicles with trypsin inhibitor. low pH of vesicle prevents enzyme activation

9

how are symogens activated in duodenum

entereopeptidase is secreted which converts trypsinogen to trypsin

10

What is the primary stimulus for secretion of bicarbonate from pancreatic duct cells

secretin

11

function of secretion

protect duodenal epithelium from acid by secreting bicarb
gives neg feedback to stomach

12

what are the 3 phases of pancreatic seceretion

cephalic, gastric, intestinal

13

how is the cephalic phase stimulated

sight, smell, taste, masticulation

14

how is the gastric phase stimulated

distension, gastrin, peptides/peptone

15

how is the intestinal phase stimulated

amino acids
fatty acids
H+

16

how is cephalic phase regulated

vagal pathway

17

how is gastric phase regulated

vagal/gastrin pwathway

18

how is intestinal phase reulgated

CCK, secretion, enteropancreatic reflex

19

what is the stimulus for returning the levels of pancreatic secretion from the fed state to interdigestive state

release of peptide YY and somatostatin

20

how does blood move through the liver

form portal vein to central vein

21

how does bile move through the liver

from the central vein to the portal vein

22

uptake in liver

freely diffused across the basolateral membrane
facilitated by FCTP

23

transport in liver

intracellular movements can be directed by binding more

24

biotransofrmation phase I

expsoe a functional group

25

biotransprotion phase II

making it more water soluble, and larger

26

secretion

secretion of produces across apical or basolateral membrane

27

what goes into blood

more water soluble

28

what goes into bile

less water soluble

29

bile salt biosynthetic pathway

cholesterol to bile acid to bile salt

30

what transforms secondary bile acids

gut bacteria

31

what secretes bile salts

liver

32

what inhibits secretion of bile into duodenum

somatostatine

33

what promotes secretion of bile into duodenum

CCK

34

what is enterohepatic cirucalation

recycling of bile

35

pancreastitis

inflammation of pancreas
decreases secretion of digestive enzymes which causes malaboprtion of dietary nutrients

36

portal hypertension

high blood pressure in protal venous system
leads to varices, splenomegaly, ascities and hepatic encephalopthy

37

jaudice

yellowing of skin due to elevated bilirubin
impaired bile excretion from liver

38

cirrhosis

fibrosis of hepatic tissue resulting in altered hepatic blood flow and function
causes portal hypertension, jaundice

39

cholestasis

impaired bile flow
caused by choleslithiasis and cholescysitis

40

cholithaisis

gallstone formation
overproduction of cholesterol or impaired production of bile salts

41

cholecystitis

inflammation of gallbladder
can be caused by stones lodged in cystic duct