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Flashcards in Autonomics Deck (17)
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1

postganglionic parasympathetic neurotransmitter is typically ______ that binds _______ receptors

Acetylcholine
Muscarinic

2

choline transport into the neuron body can be inhibited by

hemicholinium

3

the major NT of the parasympathetic system

acetylcholine

4

Release of NT at cholinergic synapse is mediated by

Ca2+ causing VAMPS and SNAPs to bind and vesicular release

5

acetylcholine is stored in vesicles by what enzyme in the neuron what what can inhibit this process

VAT
can be inhibited by VEsamicol

6

most postganglionic sympathetic neurons utilize the NT

norepinephrine

7

metyrosine action

inhibits conversion of tyrosine to dopa

8

reserpine aciton

inhibits high affinty antiporter for catecholamines located in wall of storage vesicle called VMAT (Vesicular monoamine transporter)

9

action of cocaine/tricycline antidepressants

inhibits NET (norepinephrine transporter) which carries norepinephrine and similar molecules back into cell cytoplasm
results in increase of transmitter activity because NET is partially responsible for termination of synaptic activity

10

signal termination by metabolism of adrenergic NT is mediated by what two enzymes

COMT (catechol-O-methyltransferase) and MAO (monoamine oxidase)

11

sympathetic innervation of bronchioles results in

dilation of bronchioles

12

parasympathetic innervation of the bronchioles results in

constriction of the bronchioles

13

M1, M3, M5 all induce the secondary signal


IP3/DAG --> Ca2+ increase

14

M2 and M4 all induce what secondary signal

open K channels and inhibit AC (less cAMP)

15

M1 is found in

CNS, sympathetic postganglionic neurons

16

M2 is found

in the myocardium, smooth muscle, and CNS
handles parasympathetics

17

M3 is found

endothelium - parasympathetic primarily
bronchiole smooth muscle - contraction
GI smooth muscle - contraction
GI sphincters - relaxes
GI secretion - increases
GU bladder wall - contracts
GU sphincter - relaxes