Autonomics - Adrenergic Drugs - Part 1 Flashcards
(16 cards)
Epinephrine has a higher affinity for ___ and has a predominant ___ effect
- b adrenoceptors
- ‘b’
At higher concentrations Epinephrine has an effect on ___.
a1 adrenoceptors
At high doses, epinephrine is effective at treating ___ and used for ___ in conjunction with local anaesthetic.
- anaphylaxis
- vasoconstriction
Which drug has a affinity for a1 and b1 adrenoceptors?
-Norepinephrine
(Little affinity for b2 adrenoceptors.)
Regarding adrenergic drugs, which categories are direct acting agonist?
- alpha1 and 2 agonists
* Beta2 agonists
Alpha agonist, in general, cause…
- > vasoconstriction
- > reflex bradycardia
What type of drug is Oxymetaxoline? What is it used for?
• alpha1, partial alpha2 agonist
- Nasal decongestant
- Ophthalmic hyperaemia
What are the characteristics of alpha antagonists drugs?
- > prevent sympathetically mediated vasoconstriction
- > decreased blood pressure
- > baroreceptor reflex
Phenoxybenzamine
- Non-selective antagonist
- Irreversable
- Pheochromocytoma
Phentolamine
- Reversible antagonist
* Pheochromocytoma
Major physiological response following a1 receptor activation is ___ & ___.
- increased peripheral resistance
- genitourinary smooth muscle contraction
a1 Agonists
Phenylephrine
Phenylephrine
Used as nasal decongestant.
Side effects: Hypertension
Can also be used for treatment of shock
a1 Antagonists
- Prazosin
- Tamsulosin
Prazosin
Used for treatment of hypertension and Benign Prostatic Hyperplasia
Side effects: Postural orthostatic/ hypotension related to 1st dose phenomena.
Tamsulosin
Used for Benign Prostatic Hyperplasia. More selective for genitourinary smooth muscle receptor subtype (a1A). Less postural / orthostatic hypotension
