Autonomics, Glaucoma, HTN Flashcards

1
Q

PNS cranial nerves

A

III, VII, IX, X

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2
Q

muscarinic toxicity symptoms, think

A

wet

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3
Q

nicotinic toxicity

A

fasciculations, paralysis

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4
Q

mushrooms with muscarine, can lead to food poisoning

A

inocybe, amanita

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5
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? betanechol

A

direct-acting cholinomimetic

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6
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? nicotine

A

direct-acting cholinomimetic

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7
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? pilocarpine

A

direct-acting cholinomimetic

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8
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? edrophonium

A

indirect-acting cholinomimetic

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9
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? neostigmine

A

indirect-acting cholinomimetic

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10
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? rivastigmine

A

indirect-acting cholinomimetic

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11
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? atropine

A

cholinoreceptor blocker

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12
Q

cholinesterase regenerator also used for organophosphate poisoning and nerve gas poisoning

A

pralidoxime

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13
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? benztropine

A

cholinoreceptor blocker

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14
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? ipatropium

A

cholinoreceptor blocker

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15
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? scopolamine

A

cholinoreceptor blocker

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16
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? trimethaphan

A

cholinoreceptor blocker

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17
Q

indirect-acting/direct acting cholinomimetic or cholinoreceptor blocker? hexamethonium

A

cholinoreceptor blocker

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18
Q

cholinergic crisis due to ____-medication, edrophonium (improves/weakens) muscle strength

A

over; weakens

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19
Q

used for Alzheimer’s disease

A

Rivastigmine

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20
Q

first line for organophosphate poisoning

A

Atropine

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21
Q

used for Parkinson’s (esp. tremors)

A

Biperiden, Trihexyphenidyl, Benztropine

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22
Q

preferred bronchodilator in pts with COPD and heart dse

A

ipatropium

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23
Q

used for motion sickness, applied as transdermal patch, antagonizes histamine and serotonin

A

scopolamine

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24
Q

nicotinic antagonist previously used for hypertension, now withdrawn from the market due to toxicities

A

hexamethonium/trimethaphan

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25
depolarizing neuromuscular blocker
succinylcholine
26
notable side effect of NE
reflex bradycardia
27
DOC for diagnosis of MG
edrophonium
28
DOC for tx of MG
neostigmine
29
anti-cholinesterase used for glaucoma
physostigmine
30
Tx for Sjogren/Sicca syndrome
pilocarpine
31
Tx for bowel/bladder atony
betanechol
32
Tx for acute heart failure, septic shock
B1 and D1 agonists (e.g. dobutamine, dopamine)
33
Tx for hemostasis, decongestion, spinal shock
A1 agonist (e.g. phenylephrine/pseudoephedrine)
34
Tx for bronchospasm
B2 agonist (e.g. albuterol, salmeterol)
35
Tx for premature labor
B2 agonist (e.g. terbutaline, ritodrine)
36
Tx for hypertension, glaucoma
A2 agonist (e.g.clonidine, methyldopa, aproclonidine)
37
DOC for rebound hypertension
phentolamine
38
notable SE of methyldopa
hemolytic anemia
39
nonselective A-adrenergic blockers
phenoxybenzamine, phentolamine
40
irreversible nonselective A-adrenergic used for pheochromocytoma (pre-surgical)
phenoxybenzamine
41
reversibly blocks alpha adrenergic receptors
phentolamine
42
first dose orthostatic hypotension
selective A1 blockers (e.g. prazosin)
43
BPH
selective A1 blockers (e.g. prazosin)
44
most selective for prostatic smooth muscle among selective A1 blockers
tamsulosin
45
has combined A and B blockade (hence may be used in pheochromocytoma)
labetalol
46
partial agonist activity among beta blockers, less likely to cause bronchospasm; examples
intrinsic sympathomimetic activity; pindolol, acebutolol
47
beta blockers which lack local anesthetic activity making them useful for glaucoma
timolol and betaxolol
48
beta blocker with longest half-life; shortest
nadolol; esmolol
49
beta blocker of choice for SVT
esmolol
50
blocks CNS sympathetic outflow
A2 agonists (clonidine, methyldopa)
51
TZDs act on ___ transporter in the ______
Na-Cl transporter; DCT
52
Furosemide, bumetanide, torsemide, ethacrynic acid act on ___ transporter in the ______
Na/K/2Cl, thick ascending limb of LH
53
loop diuretic with no sulfa group
ethacrynic acid
54
notable SE of loop diuretics
ototoxicity
55
obsolete drug for hypertension used to irreversibly block vesicular monoamine transporter; causes psychiatric depression, suicidal ideation
reserpine
56
advantage of A1 selectivity
reflex tachycardia is less common and less severe
57
vasodilator decreasing Ca metabolism in vascular SM; can cause drug-induced lupus, reflex tachycardia
hydralazine
58
vasodilator opening K+ channels in vascular SM causing hyperpolarization and relaxation; notable SE
minoxidil; hypertrichosis (also used for alopecia)
59
OPD DOC for SVT
verapamil
60
parenteral vasodilators
nitroprusside, fenoldopam
61
parenteral vasodilator which is also a dopamine agonist
fenoldopam
62
CCB class'n with preference to the cardiac muscle
non-dihydropyridine
63
slows ventricular remodeling, increases survival in HF, renoprotective
ACEIs, ARBs
64
how does ACEIs delay progression of DM nephropathy?
dec albumin excretion
65
renin antagonist
aliskiren
66
vasodilator which can cause cyanide toxicity; antidote
nitroprusside; amyl nitrite
67
vasodilator associated with tolerance
nitroglycerin
68
causes additive vasodilatory effect with nitrates
phosphodiesterase inhibitors (sildenafil, vardenafil, tadalafil)
69
CCB used for Raynaud's phenomenon, does not cause gingival hyperplasia
Diltiazem