B cells Flashcards
who discovered B cells in 1956?
Bruce Glick
where do most B cells develop in mammals?
bone marrow and the fetal liver
T/F: B cell development and adaptation do not continue outside the bone marrow.
false. it does continue
what is BCR?
- B cell receptor
- surface bound antibody
BCR binding ultimately leads to what?
antibody production
what are typically the points of contact with an antigen
complimentary determining regions
what happens to B cells with successfully re-arranged BCRs which pass negative selection?
they move out of the bone marrow to the periphery
do B2 follicular (FOB)s require T-dependent response?
yes
do B2 marginal zone (MZB) require T-dependent response?
no they are T-independent
do B1(a/b)B require T-dependent response?
no they are T-independent
FOB are critical for maintaining what?
long-term memory and adaptive immunity
class switching of Ig in the B cell: IFNg
IgM to IgG
class switching of Ig in the B cell: IL-4
IgM to IgE
class switching of Ig in the B cell: TGFb
IgM to IgA
when do B1 B cells arise
during fetal development only
