B lymphocyte response

Question 1

how do they mature

Answer 1

remain in bone marrow until they are mature and then spread around body concentrating in lymph nodes and the spleen

Question 2

once mature

Answer 2

each type of B lymphocyte can make one antibody molecule at this stage the antibodies remain in the cell surface membrane. each part of the antibody forms a glycoprotein receptor that can combine specifically with one antigen.

Question 3

clonal selection

Answer 3

if the antigen enters the body B lymphocyte cells with the correct cell surface receptors will recognise it and bind to it

Question 4

clonal expansion

Answer 4

these specific B lymphocytes will divide repeatedly into two main types of cell, plasma and memory cells

Question 5

primary immune response

Answer 5

• clonal selection
  -clonal expansion
  plasma cells secrete antibodies
  -plasma cells short lived but secreted antibodies stay in blood for a long time
• other B cells become memory cells that can be retained for a long time

Question 6

antigen antibody complex

Answer 6

complementary molecular shapes
molecular structure fit into eachother
forming antigen antibody complex when collide
Y shaped antigen binding sites have two binding sites so can bind to more than one antigen at a time so pathogens become clumped together through agglutination
the binding of antigens either neutralises pathogen or acts as a marker to attract phagocytes to engulf and destroy the pathogens