B2.014 Genomic DNA and Nucleic Acids Flashcards
1
Q
what is retrotransposition?
A
LINE-1 elements undergo transcription, then reverse transcription, then re integrate into a different section of the DNA
2
Q
what is hypercholesterolinemia?
A
an autosomal dominant mutation in LDLR gene; liver cant uptake LDLs, so there is an increase in serum LDL cholesterol
3
Q
what is the function of acetylation?
A
to open up chromatin for expression
4
Q
when does non-allelic homologous recombination occur?
A
in gamete formation; crossing over between homologous chromosomes, but not allele specific, Alu elements are susceptible to this due to their repetitive sequences
5
Q
what is mosaicism?
A
when one cell during development gets a mutation and then all cells that are derived from that cell also carry the mutation
