Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

IBI Test 3 > B3.047 - Anemia > Flashcards

B3.047 - Anemia Flashcards

(59 cards)

Start Studying
1
Q

what is aplastic anemia

A

myeloid stem cell disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are causes of anemia due to inadequate production

A

bone marrow failure Bone marrow infilatration/replacement Nutritional deficiency anemia of chronic disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are causes of anemia due ti ineffective production

A

myelodisplastic snydromes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

aplastic anemia is caused by

A

marrow hypoplasia and pancytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

clinical feature of aplastic anemia

A

anemia leukopenia thrombocytopenia no splenomegaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

pathogenesis of aplastic anemia

A

primarily a stem cell abnormaility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

aplastic anemia is characterized by

A

immune mediated stem cell destruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what drugs can cause aplastic anemia

A

Benzene Chloramphenicol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

genetic factors leading to aplastic anemia

A

fanconis, telomerase, acquired stem cell defects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are blood findings of aplastic anemia

A

pancytopenia normochromic reticulocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

bone marrow findings in aplastic anemia

A

hypocellular Decreased hematopoiesis increased marrow fat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is this

A

aplastic anemia

infiltrate of fat cells into bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

treatment of aplastic anemia

A

supportive

immunosuppression - try an see

angrogens

stem cell plant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

prognosis for aplastic anemia untreated

A

1 year

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

aplastic anemia with successful transplant

A

~75%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

pure red cell aplasia is what

A

disorder of erythroid progenitor cell causing decreased erythropoiesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

clinical features of pure red cell aplasia

A

anemia, pallor, weakness, fatigue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what infection is associated with pure red cell aplasia and why

A

parvovirus B19 - leads to transient drop in red blood cell count about 2 mo later

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

parvovirus B19 can cause pure red cell aplasia in what population

A

people with hemolytic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what are some things that thymoma patients can get as a paraneoplastic syndrome

A

Myasthena gravis

pure red cell aplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

describe what the image is

A

parvovirus inclusions in pure red cell aplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

treatement of pure red cell aplasia

A

treat underlying cause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

myelophthisic anemia is

A

decreased erythropoiesis due to bone marrow infiltration or replacement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

clinical features of myelophthisic anemia

Study These Flashcards
A

anemia

Feature of underlying disease

25
pathogenesis of myelophthisisc anemia
metastatic cancer fibrosis hematopoeitic neoplasms
26
pathology of myelophthisisc anemia in blood, what does it look like
normochromic/cytic teardrop shaped erythrocytes circulating nucleated RBCs granulocytic left shift reticulocytopenia
27
bone marrow pathology of myelophthissic anemia
replacement of normal elements
28
what causes the teardrop cells in myelophthisic anemia
fibrosis
29
etiology of iroin deficiency anemia
insufficient dietary intake impaired absorption Increased requirement chronic blood loss
30
iron is stored as
ferritin
31
what is ferroportin
a channel that allows iron to be transported across membranes
32
what is hepcidin
suppresses ferroportin activity blocking the transport of iron across membranes
33
what is TIBC
capacity of transferrin to bind iron, a measure (backwards) of how much iron has been bound
34
anemia of chronic disease is associated with systemic infectin due to what
chronic infection autoimmune disorders cancer
35
what is the pathogenesis of anemia of chronic disease
decreased proliferation of RBCs precursors impaired iron utilization
36
in anemia of chronic disease what is the impaired iron utilization due to
Increased hepcidin due to inflammatory mediators like IL-6 Decreased tranfer to iron to RBC precursoers in bone marrow
37
which IL is associated with hepcidin
IL-6
38
ferritin is an acute phase reactant, why is this clinically important
you can exclude iron deficiency based on ferrtin levels alone, they can be falsely increased if there is increased inflammation
39
serum iron levels in iron deficiency, anemia of chronic disease, thalassemia
40
transferrin/TIBC in
41
transferrin/TIBC in iron deficiency, anemia of chronic disease, thalassemia
42
% saturation in iron deificieny, anemia of chronic disease, thalassemia
43
ferritin levels in iron deficieny, anemia of chronic disease, thalassemia
44
soluble transferrin receptor in iron deficiency, anemia of chronic disease, thalassemia
45
megaloblastic anemia is due to what
macrocytic anemia due to deficiency of vitamin B12 or folic acid
46
if you give folate you can recover what
B12 or folic acid deficiency
47
what is vitamin B12 involved in
production of myelin in CNS
48
what is intrinsic factor
required for absorption of B12
49
Vitamin B12 is poorly absorbed if theres something wrong with their absorption processes, to replace B12 how do you give it
IV/injection
50
what can cause a B12 deficiency impaired absorption
decreased intake - vegan diet
51
impaired absorption of vitamin B12 causes
intrinsic factor deficiency malabsorption ileal resection bacterial overgrowth/blind loops fish tapeworm infection
52
folic acid deficiency is due to
decreased intake - alcoholism impared absorption increased loss increased requirement impaired utilization
53
clinical features of megaloblastic anemia
normal Neurlogic deficits - with vitamin B 12 only Demylenation of dorsal and lateral spinal tracts
54
are the B12 neurologic deficienciy symptoms reversible
no
55
features you can recognize in megaloblastic anemia
macrocytic - macroovalocytes hypersegmented neutrophils megaloblastic hematopoetic precursors
56
top - macroovalocyte bottom - hypersegnemted neutrophil indicates megaloblastic anemia
57
what type of anemia has intrinsic factor antibodies in pernicious anemia
vitamin B12 deficiency
58
why is red cell folate a better measure of folate deficiency
serum folate can go up with just a good meal, v variable
59
treatment of megaloblastic anemia
vitamin B12 supplementation (oral or parenteral) oral folic acid supplementation

IBI Test 3 (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions