B8-052 Bladder/Penile Neoplasia

Question 1

papillary urothelial neoplasms arise from […] mutations [2]

Answer 1

RAS
FGFR3

Question 2

flat urothelial carcinoma in situ arises from […] mutations [2]

Answer 2

p53
RB

Question 3

risk factors for bladder cancer

Answer 3

A carcinogen ACTS on the bladder:

Aniline dye (textile, leather, rubber)
Cyclophosphamide
Tobacco
Schistosomiasis (SCC)

Question 4

Malignant tumor arising from the urothelial lining of the renal pelvis, ureter, bladder, or urethra

Answer 4

urothelial carcinoma

Question 5

Most common type of lower urinary tract cancer; usually arises in the bladder

Answer 5

urothelial carcinoma

Question 6

benign bladder neoplasm occurring in younger patients

finger-like papillae with a fibrovascular core

Answer 6

urothelial papilloma

Question 7

benign neoplasm of the bladder

inter-anastomosing cords of urothelium that extend down into the lamina propria

Answer 7

inverted papilloma

Question 8

Tumors are often multifocal and recur (“field defect”)

Answer 8

urothelial CIS

Question 9

cytologically malignant cells within a flat urothelium

“full-thickness cytologic atypia”

Answer 9

urothelial CIS

Question 10

arises from urachal remnants or in associated with extensive intestinal metaplasia

Answer 10

adenocarcinoma of the bladder

Question 11

what type of cancer should be ruled out in diagnosis of adenocarcinoma of the bladder?

Answer 11

prostate

Question 12

[…] grade papillary tumors: usually pedunculated with a papillary surface; and noninvasive

Answer 12

low

Question 13

[…] grade papillary tumors: usually sessile and nodular/solid; and invasive (invading lamina propria or deeper tissues)

Answer 13

high

Question 14

schistosomiasis is linked to […] of the bladder

Answer 14

SCC

(classically, patient from Middle east or Africa)

Question 15

cerebral palsy and neurogenic bladder are linked to […] of the bladder

Answer 15

SCC

(due to chronic irritation via intermittent catherization)

Question 16

sheets of blue cells with nuclear moulding and crush artifact

synaptophysin and chromogranin +

Answer 16

small cell carcinoma

(indistinguishable from other small cell carcinomas; NETs)

Question 17

tumor of the detrusor muscle

positive desmin stain
negative cytokeratin stain

Answer 17

leiomyosarcoma

Question 18

immunotherapy used for CIS, high-grade, and multifocal papillary bladder tumors

Answer 18

BCG

Question 19

urothelial carcinoma tumors with FGFR3 mutations can be treated with

Answer 19

erdafitinib

Question 20

benign epithelial tumor of the penis

Answer 20

condyloma acuminatum

Question 21

malignant carcinomas of the penis [2]

Answer 21

CIS/PeIN
SCC

Question 22

what HPV serotypes cause condyloma acuminatum?

Answer 22

6, 11

Question 23

[…] DNA is significantly associated with penile SCC exhibiting basaloid changes

Answer 23

HPV

Question 24

what HPV serotypes have strong correlation to penile cancers? [3]

Answer 24

6, 16, 18

Question 25

what HPV serotype is a favorable prognostic factor for penile cancers?

Answer 25

16

Question 26

92% of recurrences of penile cancer occur within […] years

Answer 26

5

Question 27

single most important prognostic factor indicating long term survival for penile cancers

Answer 27

inguinal lymph node metastasis

Question 28

penile SCC metastasizes to the […] lymph node first

Answer 28

inguinal

Question 29

associated with urachal remnant or intestinal metaplasia

Answer 29

adenocarcinoma

(malignant glands)

Question 30

ulcerative lesion with infiltrative tumor nests and intracellular bridges

keratin pearls

Answer 30

SCC

Question 31

papillary tumors with koilocytes

Answer 31

condyloma acuminatum