bacterial cell wall structure Flashcards
(21 cards)
qualities of gram-positive cells
- thicker layer of peptidoglycan
- stain purple with gram stains
- virulence factors: wall teichoic acid, lipoteichoic acid, m proteins, mycoli acid
- may contain a glycocalyx
qualities of gram negative cells
- thinner layer of peptidoglycan
- stain red with gram stains
- virulence factors in cell wall: lps layer, porin proteins
- virulence factors: pili, fimbriae, axial filaments
- may contain glycocalyx
bacterial cell wall is composed of
peptidoglycan
peptidoglycan is made out of
nag and nam building blocks (sugar portion) linked to peptide chains (amino acid portion)
- linkage is from enzymes
peptidoglycan is a target for
antibiotics; prevents from being built
2 types of bacterial cell wall structures
gram positive and gram negative
e. coli is
gram negative
gram negative
thin layer peptidoglycan
porins
endotoxin (lipopolysaccharides)
larger periplasmic space
method of staining that distinguishes types of bacteria based on peptidoglycan cell wall
gram staining
virulence factors in the bacterial cell wall for gram-positive bacteria
teichoic acids
m protein
mycolic acid
what makes up teichoic acids
lipoteichoic acids
wall teichoic acids
provide rigidity, cause immune response (act as antigen)
lipoteichoic acids
attachment
wall teichoic acids
protrudes from the cell wall of some streptococcal species
highly susceptible to mutations
m protein
functions of m protein
increases adherence to host cells (helps attach)
prevents phagocytosis by binding directly to components on immune cells involved in phagocytosis
found in mycobacterium species
consists of waxy lipid incorporated into the cell wall
mycolic acid
functions of mycolic acid
makes cell extremely resistant to environmental stress
acts as a barrier against antibiotics and host defenses
virulence factors in bacterial cell wall for gram-negative bacteriaa
lipopolysaccharide (lps) layer
porin proteins: travels through outermost membrane
lipids proteins and polysaccharides
fastens the outer membrane of the cell to the peptidoglycan layer
breaks apart and becomes endotoxin; acts as antigen + can cause septic shock
lps layer
- form a channel through the outer membrane; responsible for movement of molecules and ions in and out of the gram-negative cell
- keeps out large molecules
- can mutate to develop resistance to antibiotics
porin proteins
some bacterial structures are a target for
antibiotics