Bacterial Meningitis

Question 1

causative agents for meningitis in kids younger than 3 mos

Answer 1

enteric, GBS, Listerial

LEG

Question 2

causative agents for meningitis in kids 3 mos to 2 years

Answer 2

H flu!!, N. meningitides, strep pneumo

Question 3

causative agents for meningitis in kids 2 - 11 years

Answer 3

strep pneumo and N. meningitides

Question 4

strep pneumo vaccine effective in young kids

Answer 4

13 capsule = prevnar

Question 5

structure of N. meningitides

Answer 5

gram - kidney bean

Question 6

4 main virulence factors for N. meningitides

Answer 6

pilli, capsule, LPS, antigenic phase varient for capsule

Question 7

reservior for N. meningitides

Answer 7

nasopharynx of humans

Question 8

endemic N. meningitides strains in US

Answer 8

B and C

Question 9

epidemic N. meningitides straind

Answer 9

A and C

Question 10

causes rash in meningococcal dz

Answer 10

endotoxin = lipooligiosaccharide

Question 11

cause of death in meningococcemia

Answer 11

pulm insufficiency

Question 12

treatment for acute N. meningitides dz and prophylaxis

Answer 12

acute = pen, cefotxime and ceftriaxone
prophylaxis = cipro

Question 13

diff between Manactra and Menomune

Answer 13

both vaccines for N. meningitides
Menomune id unconjugated and therefore has NO memory component

Manactra is conjugated to diptheria toxin = memory

Question 14

what N. meningitides strain is NOT protected by vaccines

Answer 14

B

Question 15

how is N. meningitides transmitted

Answer 15

saliva

Question 16

structure of H flu

Answer 16

small gram - rod NON-motile

Question 17

special growth medium for H flu

Answer 17

CAP (will not grow on BAP) bc needs factors X and V

Question 18

reservoir for H flu

Answer 18

humans

Question 19

distinguishing factor that allows certain strains of H flu to causes systemic dz

Answer 19

capsule = type b and f

Question 20

dz caused by encapsulated vs non-encapsulated strains of H flu

Answer 20

encapsulated = meningitis, epiglottits, arthritis, cellulitis, osteo

non-encapsulated = otitis media, respiratory dz, conjunctivis

Question 21

Vaccine for H flu?

Answer 21

yes, conjugated to diptheria toxin but only b

Question 22

structure od listeria monocytogenes

Answer 22

club shaped gram + rod

Question 23

listeria monocytogenes intracellular or extracelluar parasite

Answer 23

intracell

Question 24

what cells do listeria infect

Answer 24

mucosal epithelial and non-immune macrophages/monocytes

Question 25

source of listeria monocytogenes infections

Answer 25

Food--unpasteruized soft cheeses, hot dogs, and deli meat

Question 26

emperic treatment for otherwise healthy indiv with suspected bacterial meningitis

Answer 26

3rd gen cephlasporin (ceftriaxone) ampicillin (if listeria suspected) vanc (if resistant S. pneumo suspected) +/- dexamethisone