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Neuroscience III > Basal Ganglia Clinical Correlates > Flashcards

Basal Ganglia Clinical Correlates Flashcards

(56 cards)

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1
Q

BG impairments appear ______ to the lesion because:

A

contralateral

crossing of C-S tract through which deficits are manifested

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2
Q

PD is due to loss of dopaminergic cells in the ____. What % loss before symptomatic?

A

SNc

70-80% loss

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3
Q

Severely impaired PD patients have lost > __% of striatal dopamine.

A

90%

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4
Q

What is the most likely etiology for PD?

A

combo of accelerated aging, genetic predisposition, exposure to toxins and abnormality in oxidate mechanism

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5
Q

Oxygen free radical damage results in accumulation of:

A

lewy bodies in dopamine neurons in SNc

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6
Q

PD epidemiology:

A 
onset 40-70 yoa
infrequent before 30yoa
men>women
black 1/4 that of whites
1 million in north ameraica
60,000 new cases/year
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7
Q

What are the key clinical features of PD?

How many required to receive clinical diagnosis of PD?

A

Must have 2 of the first 3 below AND consistent response to L-dopa replacement therapy:

  1. pill rolling tremor
  2. bradykinesia and poverty of mvmnt
  3. cog-wheel rigidity
  4. loss of equilibrium and postural reflexes
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8
Q

What is micrographia?

A

small handwriting

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9
Q

What is akinesia?

A

complete loss of mvmnt

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10
Q

Bradykinesia presents as:

A 
dec. amp and speed of mvmnt
difficulty initiating
increased latency to onset of voluntary mvmnt
loss of reciprocal mvmnt
loss of facial expression
akinesia
micrographia
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11
Q

PD motor control impairments include:

A
  1. difficulty generating internally triggered mvmnt
  2. freezing
  3. festinating gait
  4. difficulty with sensory organization
  5. rigidity
  6. impaired postural control
  7. impaired eye mvmnts
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12
Q

What might a PD patient freeze?

A

difficulty in switching motor programs
inflexible program selection
challenge with divided attention
difficulty processing sensory info

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13
Q

What is the major contributor to falls with PD patients?

A

freezing

*PD has the highest fall rate of any common neurological disorder

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14
Q

PD patients have trouble with sensory organization, therefor rely more heavily on:

A

vision

can’t filter relevant from irrelevant sensory cues in the environment but vision tends to be more accurate

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15
Q

What does rigidity look like in PD?

A

flexed posture

dec. trunk rotation

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16
Q

How do impaired eye mvmnts present in PD?

A

hypometric saccades

breakdown of smooth pursuit (insufficient activation of agonist muscles)

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17
Q

What influences postural control in PD?

A

dec. LOS (esp. backwards)
dec. / ineffective strategies in response to perturbations
trunk rigidity
impaired anticipatory responses

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18
Q

What cognitive/limbic impairments are expected in PD?

A

difficulty in divided attention situations (freeze or unsteady)
concurrent depression and/or dementia as disease progresses

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19
Q

Later PD impairments include:

A

autonomic issues: orthostasis, dec. bowel motility, urinary frequency
sleep disturbances: periodic leg mvmnts, no muscle relaxation, sleep apnea

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20
Q

What secondary PD impairments might contribute to mobility difficulties?

A

contractures, dec. respiratory excursion, etc

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21
Q

What are two common PD rating scales?

A

Hoehn and Yahr

UPDRS = united PD rating scale

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22
Q

What meds are used in PD?

A 
dopamine agonist (mirapex)
L-dopa replacement therapy (sinemet)
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23
Q

Why do you want to delay drug treatment as long as possible in PD?

Study These Flashcards
A

side effects develop over time with tx, dyskinesias, on/off phenomenon

24
Q

What non-pharmacological medical management is avail for PD?

Study These Flashcards
A

DBS
can have dramatic effects
most common side is STN

25
Parkinson's plus syndrome are ddx of PD vs. other degenerative disorders. What are some similarities and differences?
early on may present with one or more PD-related signs like tremor or bradykinesia these diseases are NOT dopamine responsive and progress more RAPIDLY than PD
26
Name some parkinson's plus syndromes:
``` MSA = multiple system atrophy PSP = progressive supranuclear palsy corticobasal degeneration lewy body dementia olivopontocerebellar atrophy ```
27
Chorea is a type of _____ due to damage of the _____.
dyskinesia | damage to striatum
28
Describe sxs of chorea:
Series of continuous rapid mbmtns of face, tongue, and limbs (esp fingers/toes). Usually resemble fragments of fxnal mvmnts but are involuntary. (greek word for "dance")
29
Athetosis is a type of _____ due to damage of the _____.
dyskinesia | damage to striatum
30
Describe sxs of athetosis:
(greek word for "without position") | slow writhing mvmnts, snakelike, mostly limb involvement
31
What distinguishes chorea vs. athetosis?
athetotis involves more of limbs than chorea
32
What is an intermediate form b/w chorea and athetosis?
choreoathetosis
33
Hemiballismus is a type of _____ due to damage of the _____.
dyskineisa | damage to STN (rarely result from stroke involving sm. branch of post. cerebral artery)
34
Describe sxs of hemiballsismusL
(greek word for "jumping about") | violent flailing / ballistic mvmnts of usually one arm or one leg
35
What tis the etiology of huntington's chorea?
autosomal dominant genetic disorder (50% chance of inheritance) huntingtons allele on chromosome 4 genetic testing available consists of extended CAG trinucleotide repeat > 40 repays causes huntington's disease
36
Describe the pathological changes in huntington's chorea:
profound loss of interneurons in caudate and putamen reactive gliosis (inflammatory response) in striatum other neuron loss in Cx and Cb enlarged ventricles cell death though to be due to accumulation of oxygen free radicals or failure of mitochondrial energy metabolism
37
Describe the epidemiology of huntington's chorea:
rare: 6.5/100,000 (all races) | mean are onset 35-42 (small percentage in young and old age)
38
What diagnostic testing avail for huntington's chorea?
genetic testing MRI/CT: reduced volume in striatum PET scan: reduced D1 and D2 binding SPECT: reduced blood flow caudate > putamen
39
Hungtington's chorea usually presents initially with:
cognitive changes depression, irriability slowing cognition, decreased ability to problem solve subtle changes in coordination, choreoathetotic mvmnts in fingers
40
Later huntington's chorea sxs include:
chorea advancing distal to proximal ataxic gait with chorea choreoathetotic mvmnts of face and tongue depression and dementia
41
Dystonia is defined as:
involuntary muscle contractions causing abnormal twisting mvmnts or postures with contractions that can be sustained, intermittent, rhythmic, or tremulous
42
What is the physiology behind dystonia?
cortical disinhibition indirect BG circuit does not inhibit the surround sensory gating affected so abnormal links between sensory input and motor output abnormal body schema representations in the cortex
43
What is the age of onset for dystonia?
infantile < 2 yrs childhood 2-26 yrs adult > 26 years
44
What is the etiology of dystonia?
primary: genetic secondary: iatrogenic, tumor, stroke, trauma, CRPS plrimary +: dystonia plus other neuro signs part of another degenerative disorder like huntington's disease
45
What are some distributions of dystonia?
focal: bletherospasm (eyelid), torticollis (cervical), writers cramp, musicians segmental (whole limb) generalized (whole body)
46
How is dystonia treated?
some can be sensitive to dopamine replacement botox injections (useful for focal) maintain mobility/fitness carefully evaluate the benefit of bracing as a way to alter sensory input DO NOT stretch DBS not as reliably effective as in PD
47
What are 4 subclassifications of CP?
1. spastic 2. extrapyramidal 3. hypotonic 4. mixed and atypical types
48
Common factors in CP?
1. abnormality in motor control 2. early onset (pre/peri-natal) 2. absence of recognized underlying progressive disease
49
What are common associated features in CP?
seizures, cognitive impairment, visual and visuo-motor abnormalitites, deafness, speech and learning impairments
50
Spastic CP signs and sxs:
UMN with hyperreflexia abnormal postural reflexes sustained clonus, adductor tone dominiant tonic neck reflexes
51
What are topographic subclassifications of spastic CP?
``` hemiplegia spastic diplegia spastic quadriplegia monoplegia triplegia ```
52
What is the most common spastic CP sub classification?
spastic diplegia | due to damage of medial portion of internal capsule
53
What are sxs of extrapyramidal CP?
athetosis, chorea, choreo-athetotic
54
CP in low birth weight infants
spastic diplegia most common | predisposing factors to both CP and prematurity/low birth weight (i.e.: congenital malformation)
55
CP can influence full term infants as well:
infection majority (80%) do not have serious perinatal asphyxia can develop CP without obvious postnatal insult as well
56
What are predisposing factors for CP?
``` 1/3 have cortical dysgenesis with abnormal neuronal migration hyperbilirubinemia with athetotic CP exposure to toxins in utero infection perinatal maternal infection/fever ```

Neuroscience III (7 decks)

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