Basic Science Flashcards
(24 cards)
Importance of MMP 13
Degrades cartilagenous extracellular matrix
Antibody to sclerostin
Romosozumab
Mnemonic to memorize youngs modulus
Ceramic cost could cement poly to cancel her telephone carrier
Ceramic
Cobalt
Stainless steel
Cortical bone
Cement
Poly
Cancellous bone
Tendon
Cartilage
Component of bone that is responsible for compressive strength
Hydroxyapetite
Plates: Stiffness proportional to ____ power
third
Nails: Stiffness proportional to ____ power
fourth
Importance of SHH
Responsible for radial/ulnar
High SHH makes pinky, low makes thumb
Disorder of SHH
Responsible for fibular hemimelia
Fibular hemimelia characteristics
- Anteromedial tibial bowing
- Ball in cup tibiotalar joint
- Loss of lateral rays
AL Tibial bowing
“Always look”
Neurofibromas
AM tibial bowing
“Absent/missing”
Fibular hemimelia
PM tibial bowing
“Probably mild”
Physiologic, calcaneovalgus foot
Gene responsible for Nail Patella syndrome
LMX1B
Defect in multiple epiphyseal dysplasia
COMP
Differential for multiple epiphyseal dysplasia
Legg-Calve-Perthes
- Differentiate by bilateral involvement
Double layered patella is pathognomonic for
MED
Importance of type X collagen
Mineralization
Dumbbell shaped femurs
Kniest syndrome
Dwarf with short trunk and normal arms and limbs?
Spondylioepiphyseal dysplasia congenita
- varus hips, scoliosis
Disorder of type X collagen
Metaphyseal Chondrodysplasia, schmid type
- Metaphyseal flaring
- Affects hypertrophic zone
Morqio syndrome
“Mork”
Normal IQ
Galactose sulfatase
Keratin Sulfate
Gaucher disease
Beta glucocerebrosidase
Erlenmyer flask femurs
Osteonecrosis of femoral head
Tx: Bone marrow transplant
Differential for a tall person
Marfans
- AD
- Superior lens ectopia
- Loose joints
Homocystenuria
- AR
- Inferior lens ectopia
- Stiff joints
